Kynurenine and neopterin in chronic glomerulonephritis

Agris Martinsons, Vera Rudzite, Valerija Groma, Olga Bratslavska, Bernhard Widner, Dietmar Fuchs

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function have shown that hyperkynureninemia in 22,5% of patients develops in cases of pyridoxal-5-phosphate deficiency (hyperkynureninemia after peroral L-tryptophan load), but in 14,8% of patients through the stimulation of the cellular immune system (hyperkynureninemia at fasting state, increase of serum neopterin concentration). In all 20 patients with chronic renal failure hyperkynureninemia develops due to decreased renal function (increased serum kynurenine, neopterin and creatinine concentrations). Therefore, L-tryptophan peroral loading test with the determination of serum concentration of kynurenine before and at 3rd hour after the load, as well as the detection of serum concentration of neopterin and creatinine are helpful for the differentiation of following pathologies in patients with chronic glomerulonephritis: pyridoxal-5-phosphate deficiency, cellular immune stimulation and chronic renal failure.

Original languageEnglish
Pages (from-to)579-586
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume467
Publication statusPublished - 2000
Event9th Meeting of the International-Study-Group-for-Tryptophan-Research (ISTRY 98) - HAMBURG, GERMANY, HAMBURG, Germany
Duration: 10 Oct 199814 Oct 1998

Field of Science*

  • 1.6 Biological sciences
  • 1.4 Chemical sciences

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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