Kynurenine and neopterin in the aqueous humor of the anterior chamber of the eye and in serum of cataract patients

Guna Laganovska, Agris Martinsons, Bronislavs Pitrans, Bernhard Widner, Dietmar Fuchs

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Serum kynurenine, neopterin, selenium concentrations; neopterin concentrations in aqueous humour from anterior chamber of eye and selenium content in lenses were determined in 40 catarat patients with and in 51 - without pseudoexfoliation (PES). Significantly increased kynurenine and neopterin levels in serum and neopterin concentration in aqueous humour were observed in mature cataract patients with PES compared to whose without. These patients also presented with the lowest content of selenium in serum and lens, compared with cataract patients without PES. Increased concentrations of neopterin in serum and aqueous humour of anterior chamber of eyes suggest an increased degree of oxidative stress in patients with PES. Thus, the results support the role of oxidative stress in the development of PES in cataract patients. The decreased content of selenium may elicit immune system activation via an increased oxidative stress as it is indicated by the increased formation of kynurenine and neopterin.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume527
DOIs
Publication statusPublished - 2003

Field of Science

  • 1.4 Chemical sciences
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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