Lack of association between polymorphisms in genes MTHFR and MDR1 with risk of childhood acute lymphoblastic leukemia

Madara Kreile (Coresponding Author), Dmitrijs Rots, Linda Piekuse, Elizabete Cebura, Marika Grutupa, Zhanna Kovalova, Baiba Lace

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Background: Acute lymphoblastic leukemia (ALL) is a complex disease caused by interactions between hazardous exogenous or/and endogenous agents and many mild effect inherited susceptibility mutations. Some of them are known, but their functional roles still requireinvestigation. Age is a recognized risk factor; children with disease onset after the age of ten have worse prognosis, presumably also triggered by inherited factors. Materials and Methods: The MDR1 gene polymorphisms rs1045642, rs2032582 and MTHFR gene polymorphisms rs1801131 and rs1801133 were genotyped in 68 ALL patients in remission and 102 age and gender matched controls; parental DNA samples were also available for 42 probands. Results: No case control association was found between analyzed polymorphisms and a risk of childhood ALL development. Linkage disequilibrium was not observed in a family-based association study either. Only marginal association was observed between genetic marker rs2032582A and later disease onset (p=0.04). Conclusions: Our data suggest that late age of ALL onset could be triggered by mild effect common alleles.

Original languageEnglish
Pages (from-to)9707-9711
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number22
DOIs
Publication statusPublished - 2014

Keywords

  • Childhood cases
  • Lymphoblastic leukemia
  • MDR1
  • MTHFR
  • Polymorphisms

Field of Science

  • 3.2 Clinical medicine
  • 3.3 Health sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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