Lack of association of CCR2-64I and CCR5-Δ32 with type 1 diabetes and latent autoimmune diabetes in adults

Giovanni Gambelunghe, Mehran Ghaderi, Annalisa Brozzetti, Paola Del Sindaco, Babeck Gharizadeh, Paul Nyren, Peter Hjelmström, Liene Nikitina-Zake, Carani B. Sanjeevi, Alberto Falorni

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


It is well known that type 1 diabetes mellitus (T1DM) is a complex genetic disease resulting from the autoimmune destruction of pancreatic beta cells. Several genes have been associated with susceptibility and/or protection for T1DM, but the disease risk is mostly influenced by genes located in the class II region of the major histocompatibility complex. The attraction of leukocytes to tissues is essential for inflammation and the beginning of autoimmune reaction. The process is controlled by chemokines, which are chemotactic cytolines. Some studies have shown that CCR2-64I and CCR5-Δ32 might be important for protection of susceptibility to some immunologically-mediated disorders. In the present study, we demonstrate the lack of association between CCR2-64I and CCR5-Δ32 gene polymorphism and TIDM and we desrcibe a new method for a simple and more precise genotyping of the CCR2 gene.

Original languageEnglish
Pages (from-to)629-632
Number of pages4
JournalHuman Immunology
Issue number6
Publication statusPublished - 1 Jun 2003
Externally publishedYes


  • CCR2-64I gene
  • CCR5-Δ32 gene
  • Chemokine
  • Latent autoimmune diabetes of the adult
  • Type 1 diabetes

Field of Science*

  • 1.6 Biological sciences
  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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