Less is more: new one-step intracameral chemotherapy technique

Davide Borroni (Coresponding Author), Chiara Bonzano, Rahul Rachwani-Anil, Carlos Rocha-de Lossada, Francisco Zamorano Martín, Maria Garcia-Lorente, Elisabetta Bonzano, Hussain Ahmad Khaqan

    Research output: Contribution to journalArticlepeer-review


    Purpose: To describe the feasibility of a new one-step approach to aspirate the aqueous and apply melphalan in a single-go without repeated entries into the anterior chamber. Methods: This retrospective non-comparative study was conducted at a referral center and included 12 patients. The one-step approach is described in a step-wise manner. No complications were observed among the patients. Results: One single injection of intracameral melphalan proved to be a successful treatment in nine cases. Two patients required a second injection, which was administered two weeks after the first one following the same technique. Conclusions: This proved to be a reasonable technique for the smooth application of melphalan in the anterior chamber studded with retinoblastoma seeds. Our outcomes revealed that it is an effective, quick, and cost-effective technique. Longer-term data collection is underway, though initial findings are encouraging.

    Original languageEnglish
    Pages (from-to)218-221
    Number of pages4
    JournalRomanian journal of ophthalmology
    Issue number3
    Publication statusPublished - 2021


    • Antineoplastic Agents, Alkylating/therapeutic use
    • Humans
    • Infant
    • Melphalan
    • Retinal Neoplasms
    • Retinoblastoma
    • Retrospective Studies

    Field of Science*

    • 3.2 Clinical medicine

    Publication Type*

    • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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