Level of 25-hydroxyvitamin D in pediatric arthritis patients

Marta Laizāne (Coresponding Author), Ieva Saulīte, Sandra Feierābende, Ingrīda Rumba-Rozenfelde

Research output: Contribution to journalArticlepeer-review


Vitamin D deficiency is common and widespread globally. Vitamin D has an immunomodulatory effect, but it is still unclear whether its deficiency is associated with higher disease activity. The aim of this retrospective study was to determine the serum concentration of vitamin D in children with paediatric arthritis (juvenile idiopathic arthritis and reactive arthritis). Prevalence of hypovitaminosis D among 98 children with juvenile idiopathic arthritis and reactive arthritis was deter¬ mined and association between serum concentration of vitamin D and disease activity markers was found. Prevalence of vitamin D deficiency among children included in this study was 69.07%. Children with juvenile idiopathic arthritis had a significantly lower vitamin D level than children with reactive arthritis. There was a statistically significant moderate negative correlation between se¬ rum concentration of vitamin D and patient age, as well as a weak negative correlation between vitamin D level and patient body mass index. The significant correlations found between vitamin D level and inflammatory markers indicate that further research on the role of vitamin D in disease activity is needed.

Original languageEnglish
Pages (from-to)425-432
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Issue number5
Publication statusPublished - 2020
Externally publishedYes


  • Juvenile idiopathic arthritis
  • Reactive arthritis
  • Vitamin D

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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