TY - JOUR
T1 - Levofloxacin in veterinary medicine
T2 - a literature review
AU - Sitovs, Andrejs
AU - Sartini, Irene
AU - Giorgi, Mario
N1 - Funding Information:
Authors sincerely thank Dr. Victoria Llewelyn (College of Nursing and Health Sciences, Flinders University, Adelaide, Australia) for revision of the manuscript's grammar, and scientific comments.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/7
Y1 - 2021/7
N2 - A potent third-generation antimicrobial fluoroquinolone drug, levofloxacin was introduced into human clinical practice in 1993. Levofloxacin is also used in veterinary medicine, however its use is limited: it is completely banned for veterinary use in the EU, and used extralabel in only companion animals in the USA. Since its introduction to clinical practice, many studies have been published on levofloxacin in animal species, including pharmacokinetic studies, tissue drug depletion, efficacy, and animal microbial isolate susceptibility to levofloxacin. This literature overview highlights the most clinically relevant and scientifically important levofloxacin studies linked to the field of veterinary medicine.
AB - A potent third-generation antimicrobial fluoroquinolone drug, levofloxacin was introduced into human clinical practice in 1993. Levofloxacin is also used in veterinary medicine, however its use is limited: it is completely banned for veterinary use in the EU, and used extralabel in only companion animals in the USA. Since its introduction to clinical practice, many studies have been published on levofloxacin in animal species, including pharmacokinetic studies, tissue drug depletion, efficacy, and animal microbial isolate susceptibility to levofloxacin. This literature overview highlights the most clinically relevant and scientifically important levofloxacin studies linked to the field of veterinary medicine.
KW - levofloxacin
KW - MIC
KW - pharmacokinetics
KW - review
KW - tissue residue
UR - http://www.scopus.com/inward/record.url?scp=85105255801&partnerID=8YFLogxK
U2 - 10.1016/j.rvsc.2021.04.031
DO - 10.1016/j.rvsc.2021.04.031
M3 - Review article
C2 - 33964616
AN - SCOPUS:85105255801
SN - 0034-5288
VL - 137
SP - 111
EP - 126
JO - Research in Veterinary Science
JF - Research in Veterinary Science
ER -
