Lidocaine loaded Ca/P scaffolds for bone regeneration and local drug delivery

Dagnija Loca; Janis Locs; Juris Gulbis; Ilze Salma; Liga Berzina-Cimdina

doi:10.4028/www.scientific.net/AMR.222.289

Lidocaine loaded Ca/P scaffolds for bone regeneration and local drug delivery

Dagnija Loca, Janis Locs, Juris Gulbis, Ilze Salma, Liga Berzina-Cimdina

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

9 Citations (Scopus)

Abstract

Local drug delivery devices especially based on osteoconductive porous calcium phosphate ceramics are of clinical importance. However, the brittleness, pore structure, porosity and pore size should be controlled for their wider applications in hard tissue implants and load bearing compartments. An approach to the fabrication of the bone graft exhibiting bone regeneration function as well as the local drug delivery was made. Hydroxyapatite (HAp)/β-tricalcium phosphate (β-TCP) porous scaffolds were prepared and mechanical properties (compression strength 20MPa), porosity (>50%), pore size (60-350μm) and structure as well as interconnectivity of pores were investigated. Porous scaffolds were impregnated with 4-5 mg of lidocaine hydrochloride (LidHCl) and drug release rate was evaluated and compared for scaffolds with and without poly lactic acid (PLA), poly(ε-caprolactone) (PCL) and polyvinyl alcohol (PVA) coatings. From in vitro dissolution tests it was seen that biopolymer coatings sustained the drug release up to 12h.

Original language	English
Title of host publication	Global Research and Education
Publisher	Trans Tech Publications Ltd
Pages	289-292
Number of pages	4
ISBN (Print)	9783037850879
DOIs	https://doi.org/10.4028/www.scientific.net/AMR.222.289
Publication status	Published - 2011
Externally published	Yes
Event	9th International Conference on Global Research and Education: Inter-Academia 2010 - Riga, Latvia Duration: 9 Aug 2010 → 12 Aug 2010 Conference number: 9 https://www.businesswire.com/news/home/20110914006259/en/Research-and-Markets-Global-Research-and-Education---A-Collection-of-Papers-Presented-at-the-9th-International-Conference-on-Global-Research-Education-INTER-ACADEMIA-2010 https://andor.tuni.fi/discovery/fulldisplay?vid=358FIN_TAMPO:VU1&docid=alma9910655333505973&lang=fi&context=L

Publication series

Name	Advanced Materials Research
Volume	222
ISSN (Print)	1022-6680

Conference

Conference	9th International Conference on Global Research and Education
Country/Territory	Latvia
City	Riga
Period	9/08/10 → 12/08/10
Internet address	https://www.businesswire.com/news/home/20110914006259/en/Research-and-Markets-Global-Research-and-Education---A-Collection-of-Papers-Presented-at-the-9th-International-Conference-on-Global-Research-Education-INTER-ACADEMIA-2010 https://andor.tuni.fi/discovery/fulldisplay?vid=358FIN_TAMPO:VU1&docid=alma9910655333505973&lang=fi&context=L

Keywords*

Bioceramics
Biodegradable polymers
Calcium phosphate ceramics
Drug delivery
Hydroxyapatite

Field of Science*

3.2 Clinical medicine
2.5 Materials engineering

Publication Type*

3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

Access to Document

10.4028/www.scientific.net/AMR.222.289

Cite this

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title = "Lidocaine loaded Ca/P scaffolds for bone regeneration and local drug delivery",

abstract = "Local drug delivery devices especially based on osteoconductive porous calcium phosphate ceramics are of clinical importance. However, the brittleness, pore structure, porosity and pore size should be controlled for their wider applications in hard tissue implants and load bearing compartments. An approach to the fabrication of the bone graft exhibiting bone regeneration function as well as the local drug delivery was made. Hydroxyapatite (HAp)/β-tricalcium phosphate (β-TCP) porous scaffolds were prepared and mechanical properties (compression strength 20MPa), porosity (>50%), pore size (60-350μm) and structure as well as interconnectivity of pores were investigated. Porous scaffolds were impregnated with 4-5 mg of lidocaine hydrochloride (LidHCl) and drug release rate was evaluated and compared for scaffolds with and without poly lactic acid (PLA), poly(ε-caprolactone) (PCL) and polyvinyl alcohol (PVA) coatings. From in vitro dissolution tests it was seen that biopolymer coatings sustained the drug release up to 12h.",

keywords = "Bioceramics, Biodegradable polymers, Calcium phosphate ceramics, Drug delivery, Hydroxyapatite",

author = "Dagnija Loca and Janis Locs and Juris Gulbis and Ilze Salma and Liga Berzina-Cimdina",

year = "2011",

doi = "10.4028/www.scientific.net/AMR.222.289",

language = "English",

isbn = "9783037850879",

series = "Advanced Materials Research",

publisher = "Trans Tech Publications Ltd",

pages = "289--292",

booktitle = "Global Research and Education",

note = "9th International Conference on Global Research and Education : Inter-Academia 2010 ; Conference date: 09-08-2010 Through 12-08-2010",

url = "https://www.businesswire.com/news/home/20110914006259/en/Research-and-Markets-Global-Research-and-Education---A-Collection-of-Papers-Presented-at-the-9th-International-Conference-on-Global-Research-Education-INTER-ACADEMIA-2010, https://andor.tuni.fi/discovery/fulldisplay?vid=358FIN_TAMPO:VU1&docid=alma9910655333505973&lang=fi&context=L",

}

Loca, D, Locs, J, Gulbis, J, Salma, I & Berzina-Cimdina, L 2011, Lidocaine loaded Ca/P scaffolds for bone regeneration and local drug delivery. in Global Research and Education. Advanced Materials Research, vol. 222, Trans Tech Publications Ltd, pp. 289-292, 9th International Conference on Global Research and Education, Riga, Latvia, 9/08/10. https://doi.org/10.4028/www.scientific.net/AMR.222.289

TY - GEN

T1 - Lidocaine loaded Ca/P scaffolds for bone regeneration and local drug delivery

AU - Loca, Dagnija

AU - Locs, Janis

AU - Gulbis, Juris

AU - Salma, Ilze

AU - Berzina-Cimdina, Liga

N1 - Conference code: 9

PY - 2011

Y1 - 2011

N2 - Local drug delivery devices especially based on osteoconductive porous calcium phosphate ceramics are of clinical importance. However, the brittleness, pore structure, porosity and pore size should be controlled for their wider applications in hard tissue implants and load bearing compartments. An approach to the fabrication of the bone graft exhibiting bone regeneration function as well as the local drug delivery was made. Hydroxyapatite (HAp)/β-tricalcium phosphate (β-TCP) porous scaffolds were prepared and mechanical properties (compression strength 20MPa), porosity (>50%), pore size (60-350μm) and structure as well as interconnectivity of pores were investigated. Porous scaffolds were impregnated with 4-5 mg of lidocaine hydrochloride (LidHCl) and drug release rate was evaluated and compared for scaffolds with and without poly lactic acid (PLA), poly(ε-caprolactone) (PCL) and polyvinyl alcohol (PVA) coatings. From in vitro dissolution tests it was seen that biopolymer coatings sustained the drug release up to 12h.

AB - Local drug delivery devices especially based on osteoconductive porous calcium phosphate ceramics are of clinical importance. However, the brittleness, pore structure, porosity and pore size should be controlled for their wider applications in hard tissue implants and load bearing compartments. An approach to the fabrication of the bone graft exhibiting bone regeneration function as well as the local drug delivery was made. Hydroxyapatite (HAp)/β-tricalcium phosphate (β-TCP) porous scaffolds were prepared and mechanical properties (compression strength 20MPa), porosity (>50%), pore size (60-350μm) and structure as well as interconnectivity of pores were investigated. Porous scaffolds were impregnated with 4-5 mg of lidocaine hydrochloride (LidHCl) and drug release rate was evaluated and compared for scaffolds with and without poly lactic acid (PLA), poly(ε-caprolactone) (PCL) and polyvinyl alcohol (PVA) coatings. From in vitro dissolution tests it was seen that biopolymer coatings sustained the drug release up to 12h.

KW - Bioceramics

KW - Biodegradable polymers

KW - Calcium phosphate ceramics

KW - Drug delivery

KW - Hydroxyapatite

UR - http://www.scopus.com/inward/record.url?scp=79955837402&partnerID=8YFLogxK

U2 - 10.4028/www.scientific.net/AMR.222.289

DO - 10.4028/www.scientific.net/AMR.222.289

M3 - Conference contribution

AN - SCOPUS:79955837402

SN - 9783037850879

T3 - Advanced Materials Research

SP - 289

EP - 292

BT - Global Research and Education

PB - Trans Tech Publications Ltd

T2 - 9th International Conference on Global Research and Education

Y2 - 9 August 2010 through 12 August 2010

ER -

Lidocaine loaded Ca/P scaffolds for bone regeneration and local drug delivery

Abstract

Publication series

Conference

Keywords*

Field of Science*

Publication Type*

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