Lidocaine loaded Ca/P scaffolds for bone regeneration and local drug delivery

Dagnija Loca, Janis Locs, Juris Gulbis, Ilze Salma, Liga Berzina-Cimdina

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

9 Citations (Scopus)


Local drug delivery devices especially based on osteoconductive porous calcium phosphate ceramics are of clinical importance. However, the brittleness, pore structure, porosity and pore size should be controlled for their wider applications in hard tissue implants and load bearing compartments. An approach to the fabrication of the bone graft exhibiting bone regeneration function as well as the local drug delivery was made. Hydroxyapatite (HAp)/β-tricalcium phosphate (β-TCP) porous scaffolds were prepared and mechanical properties (compression strength 20MPa), porosity (>50%), pore size (60-350μm) and structure as well as interconnectivity of pores were investigated. Porous scaffolds were impregnated with 4-5 mg of lidocaine hydrochloride (LidHCl) and drug release rate was evaluated and compared for scaffolds with and without poly lactic acid (PLA), poly(ε-caprolactone) (PCL) and polyvinyl alcohol (PVA) coatings. From in vitro dissolution tests it was seen that biopolymer coatings sustained the drug release up to 12h.


  • Bioceramics
  • Biodegradable polymers
  • Calcium phosphate ceramics
  • Drug delivery
  • Hydroxyapatite

Field of Science*

  • 3.2 Clinical medicine
  • 2.5 Materials engineering

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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