Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

Linda A.J. Hendricks; Katja C.J. Verbeek; Janneke H.M. Schuurs-Hoeijmakers; Arjen R. Mensenkamp; Hilde Brems; Robin de Putter; Violetta C. Anastasiadou; Marie Charlotte Villy; Arne Jahn; Verena Steinke-Lange; Margherita Baldassarri; Arvids Irmejs; Mirjam M. de Jong; Thera P. Links; Edward M. Leter; Daniëlle G.M. Bosch; Hildegunn Høberg-Vetti; Marianne Tveit Haavind; Kjersti Jørgensen; Lovise Mæhle; Ana Blatnik; Joan Brunet; Esther Darder; Emma Tham; Nicoline Hoogerbrugge; Janet R. Vos

doi:10.3390/cancers16050953

Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

Linda A.J. Hendricks, Katja C.J. Verbeek, Janneke H.M. Schuurs-Hoeijmakers, Arjen R. Mensenkamp, Hilde Brems, Robin de Putter, Violetta C. Anastasiadou, Marie Charlotte Villy, Arne Jahn, Verena Steinke-Lange, Margherita Baldassarri, Arvids Irmejs, Mirjam M. de Jong, Thera P. Links, Edward M. Leter, Daniëlle G.M. Bosch, Hildegunn Høberg-Vetti, Marianne Tveit Haavind, Kjersti Jørgensen, Lovise MæhleAna Blatnik, Joan Brunet, Esther Darder, Emma Tham, Nicoline Hoogerbrugge, Janet R. Vos (Corresponding Author)

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Abstract

Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020–March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0–1 times/week physical activity than ≥2 times (OR_total-adj = 0.9 (95%CI 0.3–2.6); consumed daily about 1.2–1.8 times more often ≥1 than 0–1 glasses of alcohol (OR_total-adj = 1.2 (95%CI 0.4–4.0); OR_{non-breastcancer-index-adj} = 1.8 (95%CI 0.4–6.9); were about 1.04–1.3 times more often smokers than non-smokers (OR_total-adj = 1.04 (95%CI 0.4–2.8); OR_{non-breastcancer-index-adj} = 1.3 (95%CI 0.4–4.2)); and overweight or obesity (72%) was about 1.02–1.3 times less common (OR_total-adj = 0.98 (95%CI 0.4–2.6); OR_{non-breastcancer-index-adj} = 0.8 (95%CI 0.3–2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients’ breast cancer risk is important.

Original language	English
Article number	953
Pages (from-to)	1-10
Number of pages	10
Journal	Cancers
Volume	16
Issue number	5
DOIs	https://doi.org/10.3390/cancers16050953
Publication status	Published - Mar 2024

Keywords*

alcohol drinking
body mass index
breast neoplasm
exercise
hamartoma syndrome
multiple

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.3390/cancers16050953

Lifestyle Factors and Breast Cancer iFinal published version, 540 KBLicence: CC BY

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Hendricks, L. A. J., Verbeek, K. C. J., Schuurs-Hoeijmakers, J. H. M., Mensenkamp, A. R., Brems, H., de Putter, R., Anastasiadou, V. C., Villy, M. C., Jahn, A., Steinke-Lange, V., Baldassarri, M., Irmejs, A., de Jong, M. M., Links, T. P., Leter, E. M., Bosch, D. G. M., Høberg-Vetti, H., Tveit Haavind, M., Jørgensen, K., ... Vos, J. R. (2024). Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS). Cancers, 16(5), 1-10. Article 953. https://doi.org/10.3390/cancers16050953

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title = "Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)",

abstract = "Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020–March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0–1 times/week physical activity than ≥2 times (ORtotal-adj = 0.9 (95%CI 0.3–2.6); consumed daily about 1.2–1.8 times more often ≥1 than 0–1 glasses of alcohol (ORtotal-adj = 1.2 (95%CI 0.4–4.0); ORnon-breastcancer-index-adj = 1.8 (95%CI 0.4–6.9); were about 1.04–1.3 times more often smokers than non-smokers (ORtotal-adj = 1.04 (95%CI 0.4–2.8); ORnon-breastcancer-index-adj = 1.3 (95%CI 0.4–4.2)); and overweight or obesity (72%) was about 1.02–1.3 times less common (ORtotal-adj = 0.98 (95%CI 0.4–2.6); ORnon-breastcancer-index-adj = 0.8 (95%CI 0.3–2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients{\textquoteright} breast cancer risk is important.",

keywords = "alcohol drinking, body mass index, breast neoplasm, exercise, hamartoma syndrome, multiple",

author = "Hendricks, {Linda A.J.} and Verbeek, {Katja C.J.} and Schuurs-Hoeijmakers, {Janneke H.M.} and Mensenkamp, {Arjen R.} and Hilde Brems and {de Putter}, Robin and Anastasiadou, {Violetta C.} and Villy, {Marie Charlotte} and Arne Jahn and Verena Steinke-Lange and Margherita Baldassarri and Arvids Irmejs and {de Jong}, {Mirjam M.} and Links, {Thera P.} and Leter, {Edward M.} and Bosch, {Dani{\"e}lle G.M.} and Hildegunn H{\o}berg-Vetti and {Tveit Haavind}, Marianne and Kjersti J{\o}rgensen and Lovise M{\ae}hle and Ana Blatnik and Joan Brunet and Esther Darder and Emma Tham and Nicoline Hoogerbrugge and Vos, {Janet R.}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = mar,

doi = "10.3390/cancers16050953",

language = "English",

volume = "16",

pages = "1--10",

journal = "Cancers",

issn = "2072-6694",

publisher = "MDPI Multidisciplinary Digital Publishing Institute",

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Hendricks, LAJ, Verbeek, KCJ, Schuurs-Hoeijmakers, JHM, Mensenkamp, AR, Brems, H, de Putter, R, Anastasiadou, VC, Villy, MC, Jahn, A, Steinke-Lange, V, Baldassarri, M, Irmejs, A, de Jong, MM, Links, TP, Leter, EM, Bosch, DGM, Høberg-Vetti, H, Tveit Haavind, M, Jørgensen, K, Mæhle, L, Blatnik, A, Brunet, J, Darder, E, Tham, E, Hoogerbrugge, N & Vos, JR 2024, 'Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)', Cancers, vol. 16, no. 5, 953, pp. 1-10. https://doi.org/10.3390/cancers16050953

TY - JOUR

T1 - Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

AU - Hendricks, Linda A.J.

AU - Verbeek, Katja C.J.

AU - Schuurs-Hoeijmakers, Janneke H.M.

AU - Mensenkamp, Arjen R.

AU - Brems, Hilde

AU - de Putter, Robin

AU - Anastasiadou, Violetta C.

AU - Villy, Marie Charlotte

AU - Jahn, Arne

AU - Steinke-Lange, Verena

AU - Baldassarri, Margherita

AU - Irmejs, Arvids

AU - de Jong, Mirjam M.

AU - Links, Thera P.

AU - Leter, Edward M.

AU - Bosch, Daniëlle G.M.

AU - Høberg-Vetti, Hildegunn

AU - Tveit Haavind, Marianne

AU - Jørgensen, Kjersti

AU - Mæhle, Lovise

AU - Blatnik, Ana

AU - Brunet, Joan

AU - Darder, Esther

AU - Tham, Emma

AU - Hoogerbrugge, Nicoline

AU - Vos, Janet R.

PY - 2024/3

Y1 - 2024/3

N2 - Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020–March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0–1 times/week physical activity than ≥2 times (ORtotal-adj = 0.9 (95%CI 0.3–2.6); consumed daily about 1.2–1.8 times more often ≥1 than 0–1 glasses of alcohol (ORtotal-adj = 1.2 (95%CI 0.4–4.0); ORnon-breastcancer-index-adj = 1.8 (95%CI 0.4–6.9); were about 1.04–1.3 times more often smokers than non-smokers (ORtotal-adj = 1.04 (95%CI 0.4–2.8); ORnon-breastcancer-index-adj = 1.3 (95%CI 0.4–4.2)); and overweight or obesity (72%) was about 1.02–1.3 times less common (ORtotal-adj = 0.98 (95%CI 0.4–2.6); ORnon-breastcancer-index-adj = 0.8 (95%CI 0.3–2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients’ breast cancer risk is important.

AB - Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020–March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0–1 times/week physical activity than ≥2 times (ORtotal-adj = 0.9 (95%CI 0.3–2.6); consumed daily about 1.2–1.8 times more often ≥1 than 0–1 glasses of alcohol (ORtotal-adj = 1.2 (95%CI 0.4–4.0); ORnon-breastcancer-index-adj = 1.8 (95%CI 0.4–6.9); were about 1.04–1.3 times more often smokers than non-smokers (ORtotal-adj = 1.04 (95%CI 0.4–2.8); ORnon-breastcancer-index-adj = 1.3 (95%CI 0.4–4.2)); and overweight or obesity (72%) was about 1.02–1.3 times less common (ORtotal-adj = 0.98 (95%CI 0.4–2.6); ORnon-breastcancer-index-adj = 0.8 (95%CI 0.3–2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients’ breast cancer risk is important.

KW - alcohol drinking

KW - body mass index

KW - breast neoplasm

KW - exercise

KW - hamartoma syndrome

KW - multiple

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U2 - 10.3390/cancers16050953

DO - 10.3390/cancers16050953

M3 - Article

AN - SCOPUS:85187482396

SN - 2072-6694

VL - 16

SP - 1

EP - 10

JO - Cancers

JF - Cancers

IS - 5

M1 - 953

ER -

Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

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