Linkage between mitochondrial genome alterations, telomere length and aging population

Egija Zole, Krista Zadinane, Liana Pliss, Renate Ranka

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We studied telomere length (TL) and mitochondrial DNA (mtDNA) copy number variations in individuals from Latvian Caucasian population in different age groups. We showed a positive correlation between TL and mtDNA copy number in individuals of up to 90 years of age; however, this correlation was not observed in the 90–100 years age group. While TL shortened with age and mtDNA content decreased with increasing age, in this study it was observed that mtDNA copy number in nonagenarians was slightly higher than in the 60–89 years age group. The presence of heteroplasmy in the mtDNA HVS-I control region did not correlate with TL and mtDNA copy number. TL and mtDNA values also did not differ between mitochondrial haplogroups. In conclusion, while both TL and mtDNA are involved in the aging process and link between these cell components exists, nonagenarians may have differences in senescence-related pathways and systems, which may function as a protective mechanism that allows them to live longer.

Original languageEnglish
Pages (from-to)431-438
Number of pages8
JournalMitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis
Volume29
Issue number3
DOIs
Publication statusPublished - 3 Apr 2018

Keywords*

  • haplogroups
  • heteroplasmy
  • Mitochondria
  • mtDNA copy number
  • nonagenarians
  • telomeres

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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