Liver status and outcomes in patients without previous known liver disease receiving anticoagulant therapy for venous thromboembolism

Diego Martínez-Urbistondo (Coresponding Author), Rocío G de la Garza, Paula Villares-Fernández, Carme Font, Sebastian Schellong, Juan José López-Núñez, Aída Gil-Díaz, María Del Carmen Díaz-Pedroche, Jana Hirmerova, Manuel Monreal, RIETE Investigators, Andris Skride (Member of the Working Group)

Research output: Contribution to journalArticlepeer-review

Abstract

The association between elevated liver enzymes or FIB-4 (fibrosis index 4) and outcome in patients with venous thromboembolism (VTE) has not been evaluated. Data from patients in RIETE (Registro Informatizado Enfermedad TromboEmbólica) were used to assess the association between elevated liver enzymes or FIB-4 levels and the rates of major bleeding or death in apparent liver disease-free patients with acute VTE under anticoagulation therapy. A total of 6206 patients with acute VTE and without liver disease were included. Of them, 92 patients had major bleeding and 168 died under anticoagulation therapy. On multivariable analysis, patients with elevated liver enzymes were at increased mortality risk (HR: 1.58; 95% CI: 1.10-2.28), while those with FIB-4 levels > 2.67 points were at increased risk for major bleeding (HR: 1.69; 95% CI: 1.04-2.74). Evaluation of liver enzymes and FIB-4 index at baseline in liver disease-free patients with VTE may provide additional information on the risk for major bleeding or death during anticoagulation.

Original languageEnglish
Number of pages10
JournalInternal and Emergency Medicine
DOIs
Publication statusE-pub ahead of print - 9 Oct 2021
Externally publishedYes

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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