Local Anaesthetics: What Can We Expect More than Pain Relief?

This problem–solving article considers positive and negative non-analgesic actions of local anaesthetics, which may play a significant role in patient morbidity and mortality. Direct impact on inflammatory and immune substances and cells leads to antibacterial, anti-inflammatory, immunomodulating and systemic functions of numerous local anaesthetics. Local anaesthetics used perioperatively locally in continuous infusions or in systemic circulation reach and maintain safe and effective rates, but myotoxic and tissue growth-inhibiting effects should be taken in account.