Local Neuroimmunoendocrine System in Children with Colon Dysmotility

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Immunohistochemical (IMH) and ultrastructural investigations of colon biopsies in children with colonic dysmotility revealed two patterns of arrangement of the neuroendocrine system. In the first, many neuroendocrine cells (NC) and a rich network of immunoreactive nerve fibers were found. The second pattern is characterized by few NC in surface epithelium and crypts, few immunoreactive nerve fibers, absence
of ganglion cells, but selectively neuropeptide Y (NPY) containing neurones in and around subepithelial lymphocyte aggregations, and abundant plasma cells. Edematous unmyelinated axons were features of
both patterns. It has to remain focus of future research whether these patterns reflect different ways of the neuroendocrine and immune system in children to react to colon dysmotility or whether they are involved in causing it.
Original languageEnglish
Title of host publicationMedicīna, II
Place of PublicationRīga
PublisherLatvijas Universitāte
Publication statusPublished - 2001
Externally publishedYes

Publication series

NameLatvijas Universitātes Zinātniskie raksti
ISSN (Print)1407-2157


  • colon dysmotility
  • neuroimmunoendocrine system
  • neuropeptides

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.2. Articles or chapters in other proceedings other than those included in 3.1., with an ISBN or ISSN code


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