Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient

Per M. Humpert; U. Bärtsch; I. Konrade; H. P. Hammes; M. Morcos; M. Kasper; A. Bierhaus; P. P. Nawroth

doi:10.1055/s-2005-872886

Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient

Per M. Humpert, U. Bärtsch, I. Konrade, H. P. Hammes, M. Morcos, M. Kasper, A. Bierhaus, P. P. Nawroth

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.

Original language	English
Pages (from-to)	538-540
Number of pages	3
Journal	Experimental and Clinical Endocrinology and Diabetes
Volume	113
Issue number	9
DOIs	https://doi.org/10.1055/s-2005-872886
Publication status	Published - Oct 2005
Externally published	Yes

Keywords*

Bone marrow cells
Type 2 diabetes
Wound healing

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-2005-872886

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title = "Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient",

abstract = "We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.",

keywords = "Bone marrow cells, Type 2 diabetes, Wound healing",

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year = "2005",

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doi = "10.1055/s-2005-872886",

language = "English",

volume = "113",

pages = "538--540",

journal = "Experimental and Clinical Endocrinology and Diabetes",

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T1 - Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient

AU - Humpert, Per M.

AU - Bärtsch, U.

AU - Konrade, I.

AU - Hammes, H. P.

AU - Morcos, M.

AU - Kasper, M.

AU - Bierhaus, A.

AU - Nawroth, P. P.

PY - 2005/10

Y1 - 2005/10

N2 - We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.

AB - We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.

KW - Bone marrow cells

KW - Type 2 diabetes

KW - Wound healing

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U2 - 10.1055/s-2005-872886

DO - 10.1055/s-2005-872886

M3 - Article

C2 - 16235157

AN - SCOPUS:27744434435

SN - 0947-7349

VL - 113

SP - 538

EP - 540

JO - Experimental and Clinical Endocrinology and Diabetes

JF - Experimental and Clinical Endocrinology and Diabetes

IS - 9

ER -

Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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