Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient

Per M. Humpert, U. Bärtsch, I. Konrade, H. P. Hammes, M. Morcos, M. Kasper, A. Bierhaus, P. P. Nawroth

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.

Original languageEnglish
Pages (from-to)538-540
Number of pages3
JournalExperimental and Clinical Endocrinology and Diabetes
Volume113
Issue number9
DOIs
Publication statusPublished - Oct 2005
Externally publishedYes

Keywords

  • Bone marrow cells
  • Type 2 diabetes
  • Wound healing

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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