Long-term complications evidenced studying the explanted Gore® HELEX® atrial septal defect occluder seven years after implantation: a case report

Jurijs Sekretarjovs, Mārtiņš Kalējs, Ainārs Rudzītis, Ivars Brečs, Hermanis Sorokins, Sandra Skuja, Pēteris Stradiņš, Valērija Groma

Research output: Contribution to journalArticlepeer-review

Abstract

We present the results of the first morphological study of a Gore® HELEX® Septal Occluder 30 mm that was explanted seven years after interventional implantation due to a significant left-to-right shunt (7 mm) which resulted from the stretching of the concomitant patent foramen ovale by the occluder after atrial septal defect closure. Complete endothelialization of the surface of the device, the formation of the connective tissue around the implant, minor chronic inflammation, the appearance of foreign body giant cells and weakened myocardial cells adjacent to the implant as well as enhanced expression of matrix metalloproteinases were demonstrated.
Original languageEnglish
Pages (from-to)105-112
JournalPapers on Anthropology
Volume26
Issue number2
DOIs
Publication statusPublished - 18 Sep 2017

Keywords

  • Atrial septal defect
  • Gore® HELEX® septal occlude
  • matrix metalloproteinases, myocardium

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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