Long-term dynamics of gastric biomarkers after eradication of Helicobacter pylori infection

Ilva Daugule, Agnese Ruskule, Georgijs Moisejevs, Dace Rudzite, Laimas Jonaitis, Dainius Janciauskas, Gediminas Kiudelis, Limas Kupcinskas, Marcis Leja

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background: Secretion of pepsinogen I (PgI), pepsinogen II (PgII), fasting gastrin-17 (fG-17) and stimulated gastrin-17 (sG-17) changes after Helicobacter pylori eradication. Few data are available on the long-term dynamics of gastric biomarkers after H. pylori eradication. The aim of this study was to investigate the dynamics of gastric biomarkers in H. pylori-positive patients after eradication over a 3-year period and to compare the levels with initially H. pylori-negative patients. Materials and methods: Blood samples for the detection of gastric biomarkers were obtained from dyspeptic patients coming for upper gastrointestinal endoscopy. In H. pylori-positive patients, after eradication therapy, three follow-up blood samples were drawn after 12, 24 and 36 months; in H. pylori-negative patients, two samples were taken - at 12 and after 30 months. Median values of biomarkers in follow-up samples were compared with the baseline sample. Results: The final sample included 110 patients (median age 67 years, M/F ratio 27/83). In patients after H. pylori eradication (n = 83) PgI, PgII, fG-17 and sG-17 had decreased significantly during a 36-month period, whereas the PgI/PgII ratio had increased significantly from 5.59 to 11.64. Conclusion: In H. pylori-positive dyspeptic patients, after eradication therapy, a decrease in PgI, PgII, fG-17 and sG-17 was observed after 36 months whereas an increase in the PgI/II ratio suggested an improvement in gastric atrophy. The median levels of gastric biomarkers in patients after H. pylori eradication therapy may become similar to biomarker levels among initially H. pylori-negative individuals.

Original languageEnglish
Pages (from-to)501-505
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number5
Publication statusPublished - 14 Apr 2015
Externally publishedYes


  • Atrophic gastritis
  • Gastric biomarkers
  • Helicobacter pylori

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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