Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma

Li Fu Hu; Gudny Eiriksdottir; Tatyana Lebedeva; Irina Kholodniouk; Andrei Alimov; Fu Chen; Yan Luo; Eugene R. Zabarovsky; Sigurdur Ingvarsson; George Klein; Ingemar Ernberg

doi:10.1002/(SICI)1098-2264(199610)17:2<118::AID-GCC7>3.3.CO;2-M

Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma

Li Fu Hu
, Gudny Eiriksdottir
, Tatyana Lebedeva
, Irina Kholodniouk
, Andrei Alimov
, Fu Chen
, Yan Luo
, Eugene R. Zabarovsky
, Sigurdur Ingvarsson
, George Klein
, Ingemar Ernberg

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

We have examined 17 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte DNA from the same patients. Ten polymorphic microsatellite markers were used between 3p13 and 3p26. Allelic loss was observed in 12 samples (70%). Two loci were most frequently affected: D3S1067 (3p21.1-14.3) in 60% and D3S1217 (3p14.2-14.1) in 58%. One tumor seemed to have a homozygous deletion at 3p26, detected by the D3S1297 marker. Analysis of the clinical data showed that an increased number of aberrations in 3p was correlated with more advanced tumor stages.

Original language	English
Pages (from-to)	118-126
Number of pages	9
Journal	Genes Chromosomes and Cancer
Volume	17
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1098-2264(199610)17:2<118::AID-GCC7>3.3.CO;2-M
Publication status	Published - Oct 1996
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Field of Science*

1.6 Biological sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1002/(SICI)1098-2264(199610)17:2<118::AID-GCC7>3.3.CO;2-M

Cite this

@article{9f08110dbcb54a87bc8320a16dd5a4a0,

title = "Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma",

abstract = "We have examined 17 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte DNA from the same patients. Ten polymorphic microsatellite markers were used between 3p13 and 3p26. Allelic loss was observed in 12 samples (70\%). Two loci were most frequently affected: D3S1067 (3p21.1-14.3) in 60\% and D3S1217 (3p14.2-14.1) in 58\%. One tumor seemed to have a homozygous deletion at 3p26, detected by the D3S1297 marker. Analysis of the clinical data showed that an increased number of aberrations in 3p was correlated with more advanced tumor stages.",

author = "Hu, \{Li Fu\} and Gudny Eiriksdottir and Tatyana Lebedeva and Irina Kholodniouk and Andrei Alimov and Fu Chen and Yan Luo and Zabarovsky, \{Eugene R.\} and Sigurdur Ingvarsson and George Klein and Ingemar Ernberg",

year = "1996",

month = oct,

doi = "10.1002/(SICI)1098-2264(199610)17:2<118::AID-GCC7>3.3.CO;2-M",

language = "English",

volume = "17",

pages = "118--126",

journal = "Genes Chromosomes and Cancer",

issn = "1045-2257",

publisher = "Wiley-Liss Inc.",

number = "2",

}

TY - JOUR

T1 - Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma

AU - Hu, Li Fu

AU - Eiriksdottir, Gudny

AU - Lebedeva, Tatyana

AU - Kholodniouk, Irina

AU - Alimov, Andrei

AU - Chen, Fu

AU - Luo, Yan

AU - Zabarovsky, Eugene R.

AU - Ingvarsson, Sigurdur

AU - Klein, George

AU - Ernberg, Ingemar

PY - 1996/10

Y1 - 1996/10

N2 - We have examined 17 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte DNA from the same patients. Ten polymorphic microsatellite markers were used between 3p13 and 3p26. Allelic loss was observed in 12 samples (70%). Two loci were most frequently affected: D3S1067 (3p21.1-14.3) in 60% and D3S1217 (3p14.2-14.1) in 58%. One tumor seemed to have a homozygous deletion at 3p26, detected by the D3S1297 marker. Analysis of the clinical data showed that an increased number of aberrations in 3p was correlated with more advanced tumor stages.

AB - We have examined 17 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte DNA from the same patients. Ten polymorphic microsatellite markers were used between 3p13 and 3p26. Allelic loss was observed in 12 samples (70%). Two loci were most frequently affected: D3S1067 (3p21.1-14.3) in 60% and D3S1217 (3p14.2-14.1) in 58%. One tumor seemed to have a homozygous deletion at 3p26, detected by the D3S1297 marker. Analysis of the clinical data showed that an increased number of aberrations in 3p was correlated with more advanced tumor stages.

UR - https://www.scopus.com/pages/publications/10544245679

U2 - 10.1002/(SICI)1098-2264(199610)17:2<118::AID-GCC7>3.3.CO;2-M

DO - 10.1002/(SICI)1098-2264(199610)17:2<118::AID-GCC7>3.3.CO;2-M

M3 - Article

C2 - 8913729

AN - SCOPUS:10544245679

SN - 1045-2257

VL - 17

SP - 118

EP - 126

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

IS - 2

ER -

Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma

Abstract

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Field of Science*

Publication Type*

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