Recent studies indicate that decreased eosinophil (EO) count may be a marker of severe infection. These studies were performed on relatively small adult cohorts, there is virtually no data on possible clinical relevance of eosinopenia in pediatric practice. We present a retrospective study of 166379 parallel CRP and clinical blood tests (CBT) in pediatric patients (newborn - 17 years); samples with EO>1.5x10E9/L (high risk of end organ damage) were excluded. The tests were performed in Children’s Clinical University Hospital Laboratory in 2013-2019 (WBC and EO on Sysmex XN 2000; CRP on Cobas 6000). Anonymized results were retrieved from Hospital LIS, split by age groups, gender, WBC status and clinical profile; CRP cutoff points of 5mg/dL and 50mg/dL were applied. Data were analyzed by IBM SPSS v25 (Pearson, regression with weight estimation, Kruskal-Wallis). EO percentage highly significantly correlated with CRP level, CRP>5mg/dL rate and CRP>50mg/dL rate (p<E-500 for all), regression analysis demonstrated that this relation is independent from age, WBC count and absolute EO count. Samples with EO<0.2% (21.7% tests) had median CRP 9.11mg/dL, CRP>5mg/dL rate 61.1% and CRP>50mg/dL rate 16.0%; samples with EO 0.2-1% (24.1% tests), respectively, 5.78mg/dL, 52.4% and 12.2%; EO>1% (54.2% tests) - 1.91mg/dL, 37.0% and 7.2%; all differences highly significant in Kruskal-Wallis test (p< E-500 in all instances). Similar distribution was seen in all age groups, both genders, patients with low, normal or elevated WBC and in most clinical profiles (emergency, neonatology, surgery, therapy, hematology), except ICU (no relation) and infectology (reverse, CRP higher in samples with EO>1%). Relative eosinopenia is a readily available additional parameter for evaluation of inflammation in pediatric patients, it discriminates samples with elevated CRP at EO values <0.2%. Further study of clinical correlations, intermediate interval of 0.2-1% and of clinical profiles where 0.2% rule is not applicable would be of interest.
- 3.4. Other publications in conference proceedings (including local)