Low prevalence of celiac disease among patients with functional gastrointestinal disorders in Latvia

Alise Dekante, Ilva Daugule, Sergejs Pavlovics, Ilze Kikuste, Inese Polaka, Lilian Tzivian, Ilona Kojalo, Viesturs Putnins, Ivars Tolmanis, Ingrida Rumba-Rozenfelde, Sarmite Boka, Aigars Vanags, Marcis Leja

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background & Aims: Studies suggest that the prevalence of celiac disease (CD) is increased in individuals with functional gastrointestinal disorders (FGIDs), in particular, irritable bowel syndrome (IBS); however, the evidence is conflicting. We aimed to analyze the prevalence of CD in patients with FGIDs in Latvia. Methods: This retrospective study included patients with FGIDs, referred for a gastroenterologist consultation in a secondary gastroenterology practice unit. Patients were divided into three groups – patients only with IBS (IBS group), patients only with functional dyspepsia (FD) (FD group), patients with mixed symptoms IBS and FD (Mixed group). Patient levels of tissue transglutaminase IgA (tTG-IgA) and/or antiendomysial IgA group antibodies (EMA-IgA) were evaluated. Four duodenal biopsies were obtained and reported according to Marsh classification. Patients diagnosed or being referred for confirmation of CD were excluded from the study. Results: Overall, 1,833 FGIDs patients were enrolled. Celiac serology was available for 1,570 patients, duodenal histology for 582 patients, both histology and serology for 319 patients. In total, celiac seropositivity was present in 1.78% (28/1570) (3.18% in IBS group, 0.90% in FD group and 1.11% of cases in the mixed group). Fifteen patients had histopathological changes (2.58%; 15/582). Three IBS patients (2.36%) were both serology and biopsy positive. None of the FD patients had CD. Conclusion: Prevalence of biopsy-proven CD in patients from Latvia with FGIDs was low. Routine screening for CD could be considered only among patients with IBS.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalJournal of Gastrointestinal and Liver Diseases
Issue number1
Publication statusPublished - Mar 2020
Externally publishedYes


  • Celiac disease
  • Functional dyspepsia
  • Functional gastrointestinal disorders
  • Immunoglobulin A antibodies to endomysium
  • Immunoglobulin A antibodies to tissue transglutaminase
  • Irritable bowel syndrome

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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