Lyme disease and associated nmdar encephalitis: A case report and literature review

Natalja Predkele (Coresponding Author), Jānis Mednieks (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
15 Downloads (Pure)


We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as behavioral and speech impairments. Regardless of antibacterial treatment, no significant improvement was achieved. Methylprednisolone provided a marked improvement in the patient’s clinical signs and CSF findings. The screening did not reveal any underlying neoplasm. Taking into account the marked clinical improvement after treatment with glucocorticosteroids, we suggest that NMDAR encephalitis is a possible autoimmune complication in neuroborreliosis patients requiring additional immunotherapy.

Original languageEnglish
Pages (from-to)487-496
JournalNeurology International
Issue number4
Publication statusPublished - 28 Sept 2021


  • Autoimmune encephalitis
  • Lyme disease
  • Neuroborreliosis
  • NMDAR antibodies
  • NMDAR encephalitis

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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