Lyme disease and associated nmdar encephalitis: A case report and literature review

Natalja Predkele; Jānis Mednieks

doi:10.3390/neurolint13040048

Lyme disease and associated nmdar encephalitis: A case report and literature review

Natalja Predkele (Corresponding Author), Jānis Mednieks (Corresponding Author)

Department of Neurology and Neurosurgery

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

55 Downloads (Pure)

Abstract

We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as behavioral and speech impairments. Regardless of antibacterial treatment, no significant improvement was achieved. Methylprednisolone provided a marked improvement in the patient’s clinical signs and CSF findings. The screening did not reveal any underlying neoplasm. Taking into account the marked clinical improvement after treatment with glucocorticosteroids, we suggest that NMDAR encephalitis is a possible autoimmune complication in neuroborreliosis patients requiring additional immunotherapy.

Original language	English
Pages (from-to)	487-496
Journal	Neurology International
Volume	13
Issue number	4
DOIs	https://doi.org/10.3390/neurolint13040048
Publication status	Published - 28 Sept 2021

Keywords*

Autoimmune encephalitis
Lyme disease
Neuroborreliosis
NMDAR antibodies
NMDAR encephalitis

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.3390/neurolint13040048Licence: CC BY

Lyme Disease and Associated NMDAR EncephalitisFinal published version, 275 KBLicence: CC BY

Cite this

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title = "Lyme disease and associated nmdar encephalitis: A case report and literature review",

abstract = "We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as behavioral and speech impairments. Regardless of antibacterial treatment, no significant improvement was achieved. Methylprednisolone provided a marked improvement in the patient{\textquoteright}s clinical signs and CSF findings. The screening did not reveal any underlying neoplasm. Taking into account the marked clinical improvement after treatment with glucocorticosteroids, we suggest that NMDAR encephalitis is a possible autoimmune complication in neuroborreliosis patients requiring additional immunotherapy.",

keywords = "Autoimmune encephalitis, Lyme disease, Neuroborreliosis, NMDAR antibodies, NMDAR encephalitis",

author = "Natalja Predkele and Jānis Mednieks",

note = "Funding Information: This research publication was cost by Riga Stradins University, Riga, Latvia. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

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day = "28",

doi = "10.3390/neurolint13040048",

language = "English",

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T1 - Lyme disease and associated nmdar encephalitis

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AU - Mednieks, Jānis

PY - 2021/9/28

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N2 - We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as behavioral and speech impairments. Regardless of antibacterial treatment, no significant improvement was achieved. Methylprednisolone provided a marked improvement in the patient’s clinical signs and CSF findings. The screening did not reveal any underlying neoplasm. Taking into account the marked clinical improvement after treatment with glucocorticosteroids, we suggest that NMDAR encephalitis is a possible autoimmune complication in neuroborreliosis patients requiring additional immunotherapy.

AB - We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as behavioral and speech impairments. Regardless of antibacterial treatment, no significant improvement was achieved. Methylprednisolone provided a marked improvement in the patient’s clinical signs and CSF findings. The screening did not reveal any underlying neoplasm. Taking into account the marked clinical improvement after treatment with glucocorticosteroids, we suggest that NMDAR encephalitis is a possible autoimmune complication in neuroborreliosis patients requiring additional immunotherapy.

KW - Autoimmune encephalitis

KW - Lyme disease

KW - Neuroborreliosis

KW - NMDAR antibodies

KW - NMDAR encephalitis

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JF - Neurology International

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Lyme disease and associated nmdar encephalitis: A case report and literature review

Abstract

Keywords*

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