The amount of lysozyme in the leukocytes of 47 patients with different forms of leukemia and 6 healthy persons was investigated. The lysozyme determintion was carried out in the lysate of isolated leukocytes obtained after freezing and thawing it 7 times. The results expressed in μg per 106 cells were compared with the simultaneously determined lysozyme concentration of serum and urine. A substantial reduction of the lysozyme amount as compared with the normal value (3.1 μg/106 cells) was determined in the leukocytes of patients suffering from chronic lymphatic leukemia, acute lymphatic leukemia and the blastic crisis of chronic myeloid leukemia. Different amounts of lysozyme ranging from extremely low ones to strongly elevated ones were found in leukocytes taken from patients with acute myeloblastic and chronic monocytic leukemia. In many cases there was a lack of correlation between the lysozyme content of leukocytes on the one hand and that of serum and urine on the other hand. Possible causes underlying this lack of correlation are discussed.
|Translated title of the contribution||Lysozyme content of the leucocytes in various forms of leukemia|
|Number of pages||13|
|Publication status||Published - 1977|
Field of Science
- 3.2 Clinical medicine
- 1.1. Scientific article indexed in Web of Science and/or Scopus database