Magnesium nitrate attenuates blood pressure rise in SHR rats

Reinis Vilskersts, Janis Kuka, Edgars Liepinsh, Helena Cirule, Anita Gulbe, Ivars Kalvinsh, Maija Dambrova

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The administration of magnesium supplements and nitrates/nitrites decreases arterial blood pressure and attenuates the development of hypertension-induced complications. This study was performed to examine the effects of treatment with magnesium nitrate on the development of hypertension and its complications in spontaneously hypertensive (SHR) rats. Male SHR rats with persistent hypertension at the age of 12-13 weeks were allocated to two groups according to their arterial blood pressure. Rats from the control group received purified water, while the experimental animals from the second group received magnesium nitrate dissolved in purified water at a dose of 50 mg/kg. After four weeks of treatment, blood pressure was measured, the anatomical and functional parameters of the heart were recorded using an ultrasonograph, vascular reactivity was assayed in organ bath experiments and the cardioprotective effects of magnesium nitrate administration was assayed in an ex vivo experimental heart infarction model. Treatment with magnesium nitrate significantly increased the nitrate concentration in the plasma (from 62 ± 8 μmol/l to 111 ± 8 μmol/L), and attenuated the increase in the arterial blood pressure. In the control and magnesium nitrate groups, the blood pressure rose by 21 ± 3 mmHg and 6 ± 4 mmHg, respectively. The administration of magnesium nitrate had no effect on the altered vasoreactivity, heart function or the size of the heart infarction. In conclusion, our results demonstrate that magnesium nitrate effectively attenuates the rise in arterial blood pressure. However, a longer period of administration or earlier onset of treatment might be needed to delay the development of complications due to hypertension.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalMagnesium Research
Volume27
Issue number1
DOIs
Publication statusPublished - 2014

Keywords*

  • Heart infarction
  • Hypertension
  • Magnesium nitrate
  • Spontaneously hypertensive rat
  • Vascular reactivity

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'Magnesium nitrate attenuates blood pressure rise in SHR rats'. Together they form a unique fingerprint.

Cite this