TY - JOUR
T1 - Maternal age at birth and childhood type 1 diabetes
T2 - A pooled analysis of 30 observational studies
AU - Cardwell, Chris R.
AU - Stene, Lars C.
AU - Joner, Geir
AU - Bulsara, Max K.
AU - Cinek, Ondrej
AU - Rosenbauer, Joachim
AU - Ludvigsson, Johnny
AU - Jané, Mireia
AU - Svensson, Jannet
AU - Goldacre, Michael J.
AU - Waldhoer, Thomas
AU - Jarosz-Chobot, Przemysława
AU - Gimeno, Suely G.A.
AU - Chuang, Lee Ming
AU - Parslow, Roger C.
AU - Wadsworth, Emma J.K.
AU - Chetwynd, Amanda
AU - Pozzilli, Paolo
AU - Brigis, Girts
AU - Urbonaite, Brone
AU - Šipetić, Sandra
AU - Schober, Edith
AU - Devoti, Gabriele
AU - Ionescu-Tirgoviste, Constantin
AU - De Beaufort, Carine E.
AU - Stoyanov, Denka
AU - Buschard, Karsten
AU - Patterson, Chris C.
PY - 2010/2
Y1 - 2010/2
N2 - OBJECTIVE - The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS - Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies. RESULTS - Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I2 = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates. CONCLUSIONS - There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age.
AB - OBJECTIVE - The aim if the study was to investigate whether children born to older mothers have an increased risk of type 1 diabetes by performing a pooled analysis of previous studies using individual patient data to adjust for recognized confounders. RESEARCH DESIGN AND METHODS - Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies. RESULTS - Data were available for 5 cohort and 25 case-control studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2-9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I2 = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates. CONCLUSIONS - There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age.
UR - http://www.scopus.com/inward/record.url?scp=77449124552&partnerID=8YFLogxK
U2 - 10.2337/db09-1166
DO - 10.2337/db09-1166
M3 - Article
C2 - 19875616
AN - SCOPUS:77449124552
SN - 0012-1797
VL - 59
SP - 486
EP - 494
JO - Diabetes
JF - Diabetes
IS - 2
ER -
