MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

Giovanni Battista Migliori (Coresponding Author), Simon Tiberi, Alimuddin Zumla, Global Tuberculosis Network, Līga Kukša (Member of the Working Group)

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)

Abstract

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.

Original languageEnglish
Pages (from-to)S15-S25
JournalInternational Journal of Infectious Diseases
Volume92S
DOIs
Publication statusPublished - Mar 2020
Externally publishedYes

Keywords*

  • Adult
  • Child
  • Child, Preschool
  • Contact Tracing
  • Extensively Drug-Resistant Tuberculosis/diagnosis
  • Humans
  • Infection Control
  • Latent Tuberculosis/drug therapy
  • Practice Guidelines as Topic
  • Risk Factors
  • Tuberculosis, Multidrug-Resistant/diagnosis

Field of Science*

  • 3.2 Clinical medicine
  • 3.3 Health sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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