TY - JOUR
T1 - MDR/XDR-TB management of patients and contacts
T2 - Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network
AU - Migliori, Giovanni Battista
AU - Tiberi, Simon
AU - Zumla, Alimuddin
AU - Petersen, Eskild
AU - Chakaya, Jeremiah Muhwa
AU - Wejse, Christian
AU - Muñoz Torrico, Marcela
AU - Duarte, Raquel
AU - Alffenaar, Jan Willem
AU - Schaaf, H Simon
AU - Marais, Ben J
AU - Cirillo, Daniela Maria
AU - Alagna, Riccardo
AU - Rendon, Adrian
AU - Pontali, Emanuele
AU - Piubello, Alberto
AU - Figueroa, José
AU - Ferlazzo, Gabriella
AU - García-Basteiro, Alberto
AU - Centis, Rosella
AU - Visca, Dina
AU - D'Ambrosio, Lia
AU - Sotgiu, Giovanni
AU - Global Tuberculosis Network
A2 - Kukša, Līga
N1 - Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2020/3
Y1 - 2020/3
N2 - The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.
AB - The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.
KW - Adult
KW - Child
KW - Child, Preschool
KW - Contact Tracing
KW - Extensively Drug-Resistant Tuberculosis/diagnosis
KW - Humans
KW - Infection Control
KW - Latent Tuberculosis/drug therapy
KW - Practice Guidelines as Topic
KW - Risk Factors
KW - Tuberculosis, Multidrug-Resistant/diagnosis
U2 - 10.1016/j.ijid.2020.01.042
DO - 10.1016/j.ijid.2020.01.042
M3 - Review article
C2 - 32032752
SN - 1201-9712
VL - 92S
SP - S15-S25
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
