MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

Global Tuberculosis Network, Giovanni Battista Migliori (Coresponding Author), Līga Kukša

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)

Abstract

The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.

Original languageEnglish
Pages (from-to)S15-S25
JournalInternational Journal of Infectious Diseases
Volume92S
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Adult
  • Child
  • Child, Preschool
  • Contact Tracing
  • Extensively Drug-Resistant Tuberculosis/diagnosis
  • Humans
  • Infection Control
  • Latent Tuberculosis/drug therapy
  • Practice Guidelines as Topic
  • Risk Factors
  • Tuberculosis, Multidrug-Resistant/diagnosis

Field of Science

  • 3.2 Clinical medicine
  • 3.3 Health sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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