MENTAL DISORDERS FOLLOWING COVID-19 INFECTION: A SYSTEMATIC REVIEW OF ACUTE AND LONG-TERM PSYCHIATRIC MANIFESTATIONS AND ASSOCIATED BRAIN CHANGES

Paale Ruben Fischer, Ļubova Renemane (Coresponding Author)

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Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory tract, but sometimes also other organs, including the central nervous system (CNS). It is not
well understood how the virus affects the CNS and how frequently it happens. Our review provides insight into the occurrence of mental disorders in Corona Virus Disease 2019 (COVID-19)
patients. We also collected information about the biological basis of the susceptibility of brain cells
to SARS-CoV-2 and its implication to psychiatric manifestations. We included 24 publications in
our review, reporting psychiatric manifestations published between 31 December 2019 and 30
July 2020, using the Preferred Reporting Items for Systemic Review and Meta-Analysis statement. Mental disorders occurred in up to one-fifth of patients during the acute phase of the infection. The most common disorders included anxiety-related disorders, mood-spectrum disorders,
impaired consciousness, confusion, delirium and psychosis. The onset of psychiatric manifestations is not always preceded by respiratory symptoms, but occurs initially in COVID-19 patients.
Long-term manifestations are mainly depression and post-traumatic stress symptoms. The obtained data allow the statement that direct infection of the CNS by SARS-CoV-2 could be responsible for the observed findings. To further investigate long-term psychiatric manifestations,
randomised controlled studies must be initiated.
Original languageEnglish
Pages (from-to)347-357
JournalProceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
Volume74
Issue number6
DOIs
Publication statusPublished - 2020

Keywords*

  • mental disorders
  • psychiatry
  • brain changes
  • Covid-19
  • susceptibility
  • SARS-CoV-2

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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