MIC-A genotypes 4/5.1 and 9/9 are positively associated with type 1 diabetes mellitus in brazilian population

Valeria Tica; Liene Nikitina-Zake; Eduardo Donadi; Carani B. Sanjeevi

doi:10.1196/annals.1288.048

MIC-A genotypes 4/5.1 and 9/9 are positively associated with type 1 diabetes mellitus in brazilian population

Valeria Tica, Liene Nikitina-Zake, Eduardo Donadi, Carani B. Sanjeevi

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The aim of our study was to evaluate the frequencies of MIC-A alleles and genotypes in Brazilian patients with type 1 diabetes mellitus (T1DM) and healthy controls. MHC class I chain-related gene-A (MIC-A) has been shown to be associated with susceptibility to T1DM in different populations. We analyzed the DNA samples from 86 patients and 201 healthy controls for MIC-A by PCR amplification, and fragment sizes were determined in an ABI prism DNA sequencer. We found increased frequencies of two genotypes, MIC-A 4/5.1 (pc = 0.006; OR, 6.1) and 9/9 (pc = 0.045; OR, 5.75), in our patients (mean diagnosis age, 11.70 years; SD, 8.86; mean age, 20.44 years; SD, 12.17) compared with the controls (median age, 26.41 years; SD, 8.87).

Original language	English
Pages (from-to)	310-313
Number of pages	4
Journal	Annals of the New York Academy of Sciences
Volume	1005
DOIs	https://doi.org/10.1196/annals.1288.048
Publication status	Published - 2003
Externally published	Yes

Keywords*

Genotypes
MIC-A
T1DM

Field of Science*

1.6 Biological sciences
3.1 Basic medicine
3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1196/annals.1288.048

Cite this

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title = "MIC-A genotypes 4/5.1 and 9/9 are positively associated with type 1 diabetes mellitus in brazilian population",

abstract = "The aim of our study was to evaluate the frequencies of MIC-A alleles and genotypes in Brazilian patients with type 1 diabetes mellitus (T1DM) and healthy controls. MHC class I chain-related gene-A (MIC-A) has been shown to be associated with susceptibility to T1DM in different populations. We analyzed the DNA samples from 86 patients and 201 healthy controls for MIC-A by PCR amplification, and fragment sizes were determined in an ABI prism DNA sequencer. We found increased frequencies of two genotypes, MIC-A 4/5.1 (pc = 0.006; OR, 6.1) and 9/9 (pc = 0.045; OR, 5.75), in our patients (mean diagnosis age, 11.70 years; SD, 8.86; mean age, 20.44 years; SD, 12.17) compared with the controls (median age, 26.41 years; SD, 8.87).",

keywords = "Genotypes, MIC-A, T1DM",

author = "Valeria Tica and Liene Nikitina-Zake and Eduardo Donadi and Sanjeevi, {Carani B.}",

year = "2003",

doi = "10.1196/annals.1288.048",

language = "English",

volume = "1005",

pages = "310--313",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - MIC-A genotypes 4/5.1 and 9/9 are positively associated with type 1 diabetes mellitus in brazilian population

AU - Tica, Valeria

AU - Nikitina-Zake, Liene

AU - Donadi, Eduardo

AU - Sanjeevi, Carani B.

PY - 2003

Y1 - 2003

N2 - The aim of our study was to evaluate the frequencies of MIC-A alleles and genotypes in Brazilian patients with type 1 diabetes mellitus (T1DM) and healthy controls. MHC class I chain-related gene-A (MIC-A) has been shown to be associated with susceptibility to T1DM in different populations. We analyzed the DNA samples from 86 patients and 201 healthy controls for MIC-A by PCR amplification, and fragment sizes were determined in an ABI prism DNA sequencer. We found increased frequencies of two genotypes, MIC-A 4/5.1 (pc = 0.006; OR, 6.1) and 9/9 (pc = 0.045; OR, 5.75), in our patients (mean diagnosis age, 11.70 years; SD, 8.86; mean age, 20.44 years; SD, 12.17) compared with the controls (median age, 26.41 years; SD, 8.87).

AB - The aim of our study was to evaluate the frequencies of MIC-A alleles and genotypes in Brazilian patients with type 1 diabetes mellitus (T1DM) and healthy controls. MHC class I chain-related gene-A (MIC-A) has been shown to be associated with susceptibility to T1DM in different populations. We analyzed the DNA samples from 86 patients and 201 healthy controls for MIC-A by PCR amplification, and fragment sizes were determined in an ABI prism DNA sequencer. We found increased frequencies of two genotypes, MIC-A 4/5.1 (pc = 0.006; OR, 6.1) and 9/9 (pc = 0.045; OR, 5.75), in our patients (mean diagnosis age, 11.70 years; SD, 8.86; mean age, 20.44 years; SD, 12.17) compared with the controls (median age, 26.41 years; SD, 8.87).

KW - Genotypes

KW - MIC-A

KW - T1DM

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U2 - 10.1196/annals.1288.048

DO - 10.1196/annals.1288.048

M3 - Article

C2 - 14679081

AN - SCOPUS:1942475021

SN - 0077-8923

VL - 1005

SP - 310

EP - 313

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

MIC-A genotypes 4/5.1 and 9/9 are positively associated with type 1 diabetes mellitus in brazilian population

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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