Abstract
The aim of our study was to evaluate the frequencies of MIC-A alleles and genotypes in Brazilian patients with type 1 diabetes mellitus (T1DM) and healthy controls. MHC class I chain-related gene-A (MIC-A) has been shown to be associated with susceptibility to T1DM in different populations. We analyzed the DNA samples from 86 patients and 201 healthy controls for MIC-A by PCR amplification, and fragment sizes were determined in an ABI prism DNA sequencer. We found increased frequencies of two genotypes, MIC-A 4/5.1 (pc = 0.006; OR, 6.1) and 9/9 (pc = 0.045; OR, 5.75), in our patients (mean diagnosis age, 11.70 years; SD, 8.86; mean age, 20.44 years; SD, 12.17) compared with the controls (median age, 26.41 years; SD, 8.87).
| Original language | English |
|---|---|
| Pages (from-to) | 310-313 |
| Number of pages | 4 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1005 |
| DOIs | |
| Publication status | Published - 2003 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords*
- Genotypes
- MIC-A
- T1DM
Field of Science
- 1.6 Biological sciences
- 3.2 Clinical medicine
- 3.1 Basic medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database
ASJC Scopus subject areas
- General Neuroscience
- General Biochemistry,Genetics and Molecular Biology
- History and Philosophy of Science
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