Mildronate: Cardioprotective action through carnitine-lowering effect

Maija Dambrova, Edgars Liepinsh, Ivars Kalvinsh

Research output: Contribution to journalReview articlepeer-review

112 Citations (Scopus)

Abstract

Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myocardial energy metabolism. Biochemical and pharmacological evidence supports the hypothesis that the mechanism of action of mildronate is based on its regulatory effect on carnitine concentration, whereby mildronate treatment shifts the myocardial energy metabolism from fatty acid oxidation to the more favorable glucose oxidation under ischemic conditions. Because mildronate treatment prepares cellular metabolism and membrane structures to survive ischemic stress conditions, it is possible that mildronate could be regarded as an agent of pharmacological preconditioning.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalTrends in Cardiovascular Medicine
Volume12
Issue number6
DOIs
Publication statusPublished - Aug 2002
Externally publishedYes

Field of Science

  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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