TY - JOUR
T1 - Minimizing the dermatoscopic morphologic overlap between basal and squamous cell carcinoma
T2 - a retrospective analysis of initially misclassified tumours
AU - Neagu, N.
AU - Lallas, K.
AU - Maskalane, J.
AU - Salijuma, E.
AU - Papageorgiou, C.
AU - Gkentsidi, T.
AU - Spyridis, I.
AU - Morariu, S. H.
AU - Apalla, Z.
AU - Lallas, A.
N1 - Funding Information:
Funding source The authors received no financial support for the research, authorship, and/or publication of this article.
Publisher Copyright:
© 2020 European Academy of Dermatology and Venereology
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Background: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) have well-established dermatoscopic criteria that make them relatively easy to recognize on a clinical basis. However, even with the addition of dermatoscopy, a morphologic overlap between the two tumours does exist. Objectives: To analyse the dermatoscopic morphology of clinically and dermatoscopically misclassified BCCs and SCCs, to identify factors causing the erroneous clinical interpretation and, therefore, minimize the morphologic overlap between BCC and SCC. Methods: Retrospective study including histopathologically diagnosed BCCs or SCCs that had been clinically inversely diagnosed. Their dermatoscopic images were blindly evaluated for the presence of predefined criteria. Descriptive statistics were performed and univariate and multivariate predictors were calculated. Results: A total of 68 cases were included, 41 of which were BCCs and 27 SCCs. Most tumours in both groups were non-pigmented, ulcerated and displayed a polymorphous vascular pattern. The presence of erosions was positively associated to BCC (5.2-fold higher odds, P = 0.05), whereas scales/keratin masses were positively associated to SCC (3.7-fold higher odds, P = 0.07), although marginally not statistically significant. Conclusions: Clinically misclassified BCCs and SCCs are usually non-pigmented ulcerated tumours. Erosions and keratin masses/scales are more robust criteria as compared to vascular structures for the differential diagnosis between BCC and SCC.
AB - Background: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) have well-established dermatoscopic criteria that make them relatively easy to recognize on a clinical basis. However, even with the addition of dermatoscopy, a morphologic overlap between the two tumours does exist. Objectives: To analyse the dermatoscopic morphology of clinically and dermatoscopically misclassified BCCs and SCCs, to identify factors causing the erroneous clinical interpretation and, therefore, minimize the morphologic overlap between BCC and SCC. Methods: Retrospective study including histopathologically diagnosed BCCs or SCCs that had been clinically inversely diagnosed. Their dermatoscopic images were blindly evaluated for the presence of predefined criteria. Descriptive statistics were performed and univariate and multivariate predictors were calculated. Results: A total of 68 cases were included, 41 of which were BCCs and 27 SCCs. Most tumours in both groups were non-pigmented, ulcerated and displayed a polymorphous vascular pattern. The presence of erosions was positively associated to BCC (5.2-fold higher odds, P = 0.05), whereas scales/keratin masses were positively associated to SCC (3.7-fold higher odds, P = 0.07), although marginally not statistically significant. Conclusions: Clinically misclassified BCCs and SCCs are usually non-pigmented ulcerated tumours. Erosions and keratin masses/scales are more robust criteria as compared to vascular structures for the differential diagnosis between BCC and SCC.
UR - http://www.scopus.com/inward/record.url?scp=85079713900&partnerID=8YFLogxK
U2 - 10.1111/jdv.16207
DO - 10.1111/jdv.16207
M3 - Article
C2 - 31955467
AN - SCOPUS:85079713900
SN - 0926-9959
VL - 34
SP - 1999
EP - 2003
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 9
ER -