TY - JOUR
T1 - Mitochondrial DNA origins of the Latvian clefting population
AU - Vieira, Alexandre R.
AU - Pliss, Liana
AU - Pelnena, Inese
AU - Krumina, Astrida
AU - Baumanis, Viesturs
AU - Lace, Baiba
PY - 2011/3
Y1 - 2011/3
N2 - Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility.
AB - Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility.
KW - Cleft lip/palate
KW - Mitochondrial haplogroups
UR - http://www.scopus.com/inward/record.url?scp=79251600357&partnerID=8YFLogxK
UR - https://reader.elsevier.com/reader/sd/pii/S1567724910001698?token=00B911CEB32CCE37F197B6F77763F50D18C09AF3FEF87710410BCA77382C03D1E1603B1B44BA4485712436F18AC73036&originRegion=eu-west-1&originCreation=20210716073316
U2 - 10.1016/j.mito.2010.10.001
DO - 10.1016/j.mito.2010.10.001
M3 - Article
C2 - 20946971
AN - SCOPUS:79251600357
SN - 1567-7249
VL - 11
SP - 357
EP - 359
JO - Mitochondrion
JF - Mitochondrion
IS - 2
ER -