Mitochondrial DNA origins of the Latvian clefting population

Alexandre R. Vieira; Liana Pliss; Inese Pelnena; Astrida Krumina; Viesturs Baumanis; Baiba Lace

doi:10.1016/j.mito.2010.10.001

Mitochondrial DNA origins of the Latvian clefting population

Alexandre R. Vieira, Liana Pliss, Inese Pelnena, Astrida Krumina, Viesturs Baumanis, Baiba Lace

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility.

Original language	English
Pages (from-to)	357-359
Number of pages	3
Journal	Mitochondrion
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.mito.2010.10.001
Publication status	Published - Mar 2011
Externally published	Yes

Keywords*

Cleft lip/palate
Mitochondrial haplogroups

Field of Science*

1.6 Biological sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.mito.2010.10.001

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title = "Mitochondrial DNA origins of the Latvian clefting population",

abstract = "Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility.",

keywords = "Cleft lip/palate, Mitochondrial haplogroups",

author = "Vieira, {Alexandre R.} and Liana Pliss and Inese Pelnena and Astrida Krumina and Viesturs Baumanis and Baiba Lace",

year = "2011",

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doi = "10.1016/j.mito.2010.10.001",

language = "English",

volume = "11",

pages = "357--359",

journal = "Mitochondrion",

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TY - JOUR

T1 - Mitochondrial DNA origins of the Latvian clefting population

AU - Vieira, Alexandre R.

AU - Pliss, Liana

AU - Pelnena, Inese

AU - Krumina, Astrida

AU - Baumanis, Viesturs

AU - Lace, Baiba

PY - 2011/3

Y1 - 2011/3

N2 - Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility.

AB - Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility.

KW - Cleft lip/palate

KW - Mitochondrial haplogroups

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JO - Mitochondrion

JF - Mitochondrion

IS - 2

ER -

Mitochondrial DNA origins of the Latvian clefting population

Abstract

Keywords*

Field of Science*

Publication Type*

Access to Document

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