Mitochondrial DNA origins of the Latvian clefting population

Alexandre R. Vieira, Liana Pliss, Inese Pelnena, Astrida Krumina, Viesturs Baumanis, Baiba Lace

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Latvia has one of the highest prevalence of isolated cleft lip with or without cleft palate (CL/P) in Europe. To clarify the genetic origins of the Latvian cleft population and establish a method for genetic mapping, mitochondrial DNA variation was studied in a population affected with clefting. One-hundred and seven subjects and 351 samples from unrelated healthy volunteers representing four anthropologically, archaeologically and ethno-linguistically different regions of Latvia were selected. The case group showed a higher frequency of haplogroups U4 (p = 0.02) and U5 (p = 0.0003) than in non-U haplogroups. We hypothesize that U4 and U5 mtDNA haplotype carriers may also carry susceptibility genes for clefts. Future studies will take into consideration these definitions based on mtDNA haplotypes when analyzing genetic variations and their possible contribution to CL/P susceptibility.

Original languageEnglish
Pages (from-to)357-359
Number of pages3
Issue number2
Publication statusPublished - Mar 2011
Externally publishedYes


  • Cleft lip/palate
  • Mitochondrial haplogroups

Field of Science*

  • 1.6 Biological sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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