Mitotic catastrophe and endomitosis in tumour cells: An evolutionary key to a molecular solution

Jekaterina Erenpreisa, M. Kalejs, M. S. Cragg

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

Following genotoxic insult, p53 mutated tumour cells undergo mitotic catastrophe. This is characterised by a switch from mitosis to the endocycle. The essential difference between mitosis and the endocycle is that in the latter, DNA synthesis is uncoupled from cell division, which leads to the formation of endopolyploid cells. Recent data suggests that a return from the endocycle into mitosis is also possible. Furthermore, our observations indicate that a particular type of endocycle known as endomitosis may be involved in this return. Here we review the role of endomitosis in the somatic reduction of polyploidy during development and its postulated role in the evolution of meiosis. Finally, we incorporate these evolutionary data to help interpret our most recent observations in the tumour cell system, which indicate a role for endomitosis and meiotic regulators, in particular p39mos in the segregation of genomes (somatic reduction) of these endopolyploid cells.

Original languageEnglish
Pages (from-to)1012-1018
Number of pages7
JournalCell Biology International
Volume29
Issue number12
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

Keywords

  • Endomitosis
  • Meiotic regulators
  • Mitotic catastrophe
  • Somatic reduction
  • Tumours

Field of Science

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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