Modulation of Na, K-ATPase activity by immunoglobulins - III. Influence of an ATPase activity regulating agent "Marina" on Na, K-ATPase activity in patients with various chronic disturbances

Elena Ponomarenko, Jurijs Pokrotnieks, Janis Jirgensons, Jurijs Seleznevs, Antons Danilans, Nadezhda Shubnikova, Ivars Kalvins

Research output: Contribution to journalArticlepeer-review

Abstract

Background. In some earlier work we have demonstrated that hypotonic mineral water can change the functional activity of Na, K-ATPase both in vitro and in vivo. The current investigation was aimed at measuring of the functional activity of ATPase in erythrocytes from blood samples of patients before and after treatment with the artificially mineralised water "Marina". Methods. "Marina" -an artificial mineral water containing K+ and Mg2+ ions, was investigated by double-blind method. Treatment lasted 7 days, daily intake of "Marina" was 4 × 200 ml before meals. Na, K-ATPase activity in erythrocytes and a number of clinical indices was determined before and after the treatment. Results. After the intake of the preparation "Marina" the normal activity pattern of the Na, K-ATPase in chronic active hepatitis or atherosclerosis patients was restored. The restoration of the Na, K-ATPase activity brought about the normalization of vital clinical indices. Conclusions. The summarized data from the in vitro and in vivo experiments point to formation of Na, K-ATPase and immunoglobulin complexes as possible cause of cell disfunction and source of organic disturbances.

Original languageEnglish
Pages (from-to)617-620
Number of pages4
JournalChinese Medical Journal (Taipei)
Volume64
Issue number11
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Erythrocytes
  • Immunoglobulins
  • Na, K-ATPase

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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