Morpho-chemistry and functionality of diseased biological tissues

Marta Lange, Riccardo Cicchi, Francesco S. Pavone

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Heart and cardiovascular diseases are one of the most common in the world, in particular - arthrosclerosis. The aim of the research is to distinguish pathological and healthy tissue regions in biological samples, in this case - to distinguish collagen and lipid rich regions within the arterial wall. In the work a specific combination of such methods are used: FLIM and SHG in order to evaluate the biological tissue morphology and functionality, so that this research could give a contribution for creating a new biological tissue imaging standard in the closest future. During the study the most appropriate parameter for fluorescence lifetime decay was chosen in order to evaluate lifetime decay parameters and the isotropy of the arterial wall and deposition, using statistical methods FFT and GLCM. The research gives a contribution or the future investigations for evaluating lipid properties when it can de-attach from the arterial wall and cause clotting in the blood vessel or even a stroke.

Original languageEnglish
Title of host publicationUltrafast Nonlinear Imaging and Spectroscopy II
EditorsIam Choon Khoo, Zhiwen Liu, Demetri Psaltis
ISBN (Electronic)9781628412253
Publication statusPublished - 2014
Externally publishedYes
EventUltrafast Nonlinear Imaging and Spectroscopy II - San Diego, United States
Duration: 17 Aug 201418 Aug 2014
Conference number: 2,exact,%20spectral%20imaging%20&offset=0

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceUltrafast Nonlinear Imaging and Spectroscopy II
Country/TerritoryUnited States
CitySan Diego
Internet address


  • Atherosclerosis
  • Fluorescence lifetime imaging microscopy (FLIM)
  • Image analysis
  • Second harmonic generation (SHG) microscopy

Field of Science*

  • 1.3 Physical sciences
  • 2.6 Medical engineering

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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