Morphological and clinicaldata review of 130 primary myelofibrosis patientsin Latvia

Primary myelofibrosis is a rare myeloproliferative neoplasm, which is characterised by atypical megakaryocytes and bone marrow reticulin and/or collagen fibrosis in bone marrow biopsies. Clinical changes includes abnormal count of erythrocytes, leukocytes and platelet in routine blood smear. Hepatosplenomegaly is observed as well. There
is very little data available about epidemiology and morphological and clinical characteristics of this disease in European Union.
The aim of our research was to determine newly diagnosed PM patients’ morphological and clinical data. During the time period from 2010 to 2015 PMF was diagnosed in
130 cases. Men were 60 (46.2 %;), women – 70 (53.8 %) of all cases. Average patient age was 67.08 ± 10.09 years. About 20.2 % of all patients with primary myelofibrosis in Latvia are younger than 60 years.
Disease was diagnosed in fibrotic stage in 56.2 % (n = 73) cases. Prefibrotic stage was observed in 43.8 % (n = 57) cases. Myelofibrosis grades were as follows: MF0 33, 8 %, n = 44; MF1 17, 7 %, n = 23; MF2 29, 2 %; n = 38 and MF3 19, 2 %; n = 25. Splenomegaly was confirmed with imaging studies in 111 cases. Average size of spleen, if splenomegaly was
noticed, was 18, 3 ± 5, 02 cm. Hepatomegaly was diagnosed in 26 cases.
The average liver size in these cases was 16.12 ± 1.25 cm. Overall primary myelofibrosis patients’ morphological and clinical characteristics are similar to these data worldwide. Disease was diagnosed in fibrotic stage in more than half patients. Clinical data showedthat patients had such clinical signs as hepatosplenomegaly, anaemia,
and leucocytosis. Platelets’ level ranged from normal platelet count to severe thrombocytopenia. This research is the first which analyses primary myelofibrosis in Latvian population.