Liver biopsies of 2825 patients with various acute and chronic diseases of the liver, gall bladder or pancreas were studied by means of modern techniques of the functional morphology (histochemistry enzyme histochemistry, electron microscopy). Different icteric forms (prehepatic, hepatic and posthepatic icterus) are associated with distinct structural and functional changes of the hepatocytes and the intrahepatic bile ducts accompanied by a complex of disturbances in the bilirubin metabolism. In the early stage of icterus distinct pathogenetic and morphological differences between different forms of jaundice were found. Following secondary alterations of the liver tissue these differences are lost. The various steps of the bilirubin metabolism are then wholly disturbed.
|Translated title of the contribution||Morphological aspects concerning a hepatogenic conception of the hyperbilirubinemia|
|Number of pages||9|
|Journal||Zentralblatt fur Allgemeine Pathologie und Pathologische Anatomie|
|Publication status||Published - 1975|
Field of Science*
- 3.1 Basic medicine
- 1.1. Scientific article indexed in Web of Science and/or Scopus database