Morphopathogenesis of complete uni- and bilateral cleft lip and palate

Māra Pilmane, Ilze Akota, Benita Krivicka-Užkurele

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Clefts of lip and palate (CLP) belong to the most common anomalies with still unclear pathogenesis. We investigated palate tissue in 37 children with complete unilateral CLP and 15 children with bilateral CLP for growth factors. barx1 and apoptosis. Results. FGFR1 marked numerous structures of tissues in UCLP, but abundant - in BCLP patients of both dentition ages. Numerous cells showed strong expression of bFGF in UCLP independently from are while BCLP patient of mixed dentition demonstrated decrease of factor. NGFR more characterised BCLP. bNGF was notably decreased. TGF beta demonstrated intensive expression only in UCLP barx1 was more prominent in BCLP before mixed dentition. Apoptosis increased in BCLP. We conclude on the modulation (regeneration/exhausting) of tissue properties by the increase of FGFR1 and/or decrease of NGF in complete clefts: role of TGF beta in severity of clefts, and more variations of growth factors and apoptosis in BCLP tissue.
Original languageEnglish
Title of host publication11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT)
EditorsCER DoAmaral, ABA deAlmeida
Place of PublicationBologna
PublisherMedimond International Proceedings
Pages189-192
ISBN (Print)978-88-7587-516-9
Publication statusPublished - 2009
Event11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT) - Fortalez, Brazil
Duration: 10 Sep 200913 Sep 2009
Conference number: 11

Congress

Congress11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT)
Country/TerritoryBrazil
CityFortalez
Period10/09/0913/09/09

Field of Science*

  • 3.2 Clinical medicine
  • 3.1 Basic medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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