Morphopathogenesis of complete uni- and bilateral cleft lip and palate

Māra Pilmane; Ilze Akota; Benita Krivicka-Užkurele

Morphopathogenesis of complete uni- and bilateral cleft lip and palate

Māra Pilmane, Ilze Akota, Benita Krivicka-Užkurele

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Clefts of lip and palate (CLP) belong to the most common anomalies with still unclear pathogenesis. We investigated palate tissue in 37 children with complete unilateral CLP and 15 children with bilateral CLP for growth factors. barx1 and apoptosis. Results. FGFR1 marked numerous structures of tissues in UCLP, but abundant - in BCLP patients of both dentition ages. Numerous cells showed strong expression of bFGF in UCLP independently from are while BCLP patient of mixed dentition demonstrated decrease of factor. NGFR more characterised BCLP. bNGF was notably decreased. TGF beta demonstrated intensive expression only in UCLP barx1 was more prominent in BCLP before mixed dentition. Apoptosis increased in BCLP. We conclude on the modulation (regeneration/exhausting) of tissue properties by the increase of FGFR1 and/or decrease of NGF in complete clefts: role of TGF beta in severity of clefts, and more variations of growth factors and apoptosis in BCLP tissue.

Original language	English
Title of host publication	11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT)
Editors	CER DoAmaral, ABA deAlmeida
Place of Publication	Bologna
Publisher	Medimond International Proceedings
Pages	189-192
ISBN (Print)	978-88-7587-516-9
Publication status	Published - 2009
Event	11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT) - Fortalez, Brazil Duration: 10 Sept 2009 → 13 Sept 2009 Conference number: 11 https://www.worldcat.org/title/11th-international-congress-on-cleft-lip-and-palate-and-related-cranofacial-anomalies-cleft-fortaleza-brazil-september-10-13-2009/oclc/457130674

Congress

Congress	11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT)
Country/Territory	Brazil
City	Fortalez
Period	10/09/09 → 13/09/09
Internet address	https://www.worldcat.org/title/11th-international-congress-on-cleft-lip-and-palate-and-related-cranofacial-anomalies-cleft-fortaleza-brazil-september-10-13-2009/oclc/457130674

Field of Science*

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

Cite this

@inproceedings{336bf5c4c46f490e96d8af7844a7d6b2,

title = "Morphopathogenesis of complete uni- and bilateral cleft lip and palate",

abstract = "Clefts of lip and palate (CLP) belong to the most common anomalies with still unclear pathogenesis. We investigated palate tissue in 37 children with complete unilateral CLP and 15 children with bilateral CLP for growth factors. barx1 and apoptosis. Results. FGFR1 marked numerous structures of tissues in UCLP, but abundant - in BCLP patients of both dentition ages. Numerous cells showed strong expression of bFGF in UCLP independently from are while BCLP patient of mixed dentition demonstrated decrease of factor. NGFR more characterised BCLP. bNGF was notably decreased. TGF beta demonstrated intensive expression only in UCLP barx1 was more prominent in BCLP before mixed dentition. Apoptosis increased in BCLP. We conclude on the modulation (regeneration/exhausting) of tissue properties by the increase of FGFR1 and/or decrease of NGF in complete clefts: role of TGF beta in severity of clefts, and more variations of growth factors and apoptosis in BCLP tissue.",

author = "Māra Pilmane and Ilze Akota and Benita Krivicka-U{\v z}kurele",

year = "2009",

language = "English",

isbn = "978-88-7587-516-9",

pages = "189--192",

editor = "CER DoAmaral and ABA deAlmeida",

booktitle = "11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT)",

publisher = "Medimond International Proceedings",

note = "11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT) ; Conference date: 10-09-2009 Through 13-09-2009",

url = "https://www.worldcat.org/title/11th-international-congress-on-cleft-lip-and-palate-and-related-cranofacial-anomalies-cleft-fortaleza-brazil-september-10-13-2009/oclc/457130674",

}

Pilmane, M , Akota, I & Krivicka-Užkurele, B 2009, Morphopathogenesis of complete uni- and bilateral cleft lip and palate. in CER DoAmaral & ABA deAlmeida (eds), 11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT). Medimond International Proceedings, Bologna, pp. 189-192, 11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT), Fortalez, Brazil, 10/09/09.

Morphopathogenesis of complete uni- and bilateral cleft lip and palate. / Pilmane, Māra ; Akota, Ilze; Krivicka-Užkurele, Benita.
11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT). ed. / CER DoAmaral; ABA deAlmeida. Bologna: Medimond International Proceedings, 2009. p. 189-192.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Morphopathogenesis of complete uni- and bilateral cleft lip and palate

AU - Pilmane, Māra

AU - Akota, Ilze

AU - Krivicka-Užkurele, Benita

N1 - Conference code: 11

PY - 2009

Y1 - 2009

N2 - Clefts of lip and palate (CLP) belong to the most common anomalies with still unclear pathogenesis. We investigated palate tissue in 37 children with complete unilateral CLP and 15 children with bilateral CLP for growth factors. barx1 and apoptosis. Results. FGFR1 marked numerous structures of tissues in UCLP, but abundant - in BCLP patients of both dentition ages. Numerous cells showed strong expression of bFGF in UCLP independently from are while BCLP patient of mixed dentition demonstrated decrease of factor. NGFR more characterised BCLP. bNGF was notably decreased. TGF beta demonstrated intensive expression only in UCLP barx1 was more prominent in BCLP before mixed dentition. Apoptosis increased in BCLP. We conclude on the modulation (regeneration/exhausting) of tissue properties by the increase of FGFR1 and/or decrease of NGF in complete clefts: role of TGF beta in severity of clefts, and more variations of growth factors and apoptosis in BCLP tissue.

AB - Clefts of lip and palate (CLP) belong to the most common anomalies with still unclear pathogenesis. We investigated palate tissue in 37 children with complete unilateral CLP and 15 children with bilateral CLP for growth factors. barx1 and apoptosis. Results. FGFR1 marked numerous structures of tissues in UCLP, but abundant - in BCLP patients of both dentition ages. Numerous cells showed strong expression of bFGF in UCLP independently from are while BCLP patient of mixed dentition demonstrated decrease of factor. NGFR more characterised BCLP. bNGF was notably decreased. TGF beta demonstrated intensive expression only in UCLP barx1 was more prominent in BCLP before mixed dentition. Apoptosis increased in BCLP. We conclude on the modulation (regeneration/exhausting) of tissue properties by the increase of FGFR1 and/or decrease of NGF in complete clefts: role of TGF beta in severity of clefts, and more variations of growth factors and apoptosis in BCLP tissue.

M3 - Conference contribution

SN - 978-88-7587-516-9

SP - 189

EP - 192

BT - 11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT)

A2 - DoAmaral, CER

A2 - deAlmeida, ABA

PB - Medimond International Proceedings

CY - Bologna

T2 - 11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies (CLEFT)

Y2 - 10 September 2009 through 13 September 2009

ER -

Morphopathogenesis of complete uni- and bilateral cleft lip and palate

Abstract

Congress

Field of Science*

Publication Type*

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