Abstract
Background / Objective
Conventional B-mode ultrasound often face challenges in distinguishing parathyroid adenoma (PA) from hyperplasia (PH). This study aimed to assess the qualitative and quantitative characteristics of parathyroid gland lesions using multiparametric ultrasound (MPUS).
Methods
Consecutive 85 patients with 98 parathyroid lesions and biochemically confirmed hyperparathyroidism (HPT) were enrolled in our prospective study prior to parathyroidectomy. MPUS included B-mode ultrasound, colour-doppler (CD), elastography and contrast-enhanced ultrasound (CEUS) with the subsequent qualitative and quantitative evaluation of obtained data. The findings from MPUS were compared to histopathological results obtained post-surgery.
Results
Eighty parathyroid adenomas were well-circumscribed and hypoechoic with increased central echogenicity (47.1%), peripheral-central vascularization (53%), polar feeding vessel (98%). Fourteen PH observed to have similar ultrasound appearance but were smaller in volume (p=0.038). Hyperplasias had a tendency for marked enhancement in CEUS after quantitative analysis vs. peripherally enhanced adenomas with central wash-out. We achieved 91.2% sensitivity and 73.5% specificity, 94% positive predictive value (PPV), 87.5% negative predictive value (NPV) and 87.5% accuracy in the differentiation of parathyroid lesions prior to post-processing. Our sensitivity increased up to 98%, specificity 80%, PPV 98%, NPV 80% with an accuracy of 96.5% after quantitative analysis.
Conclusions
CEUS of parathyroid lesions showed potential in the differentiation of adenoma from hyperplasia. The quantitative analysis enhanced the sensitivity and specificity of differentiation between parathyroid lesions.
Conventional B-mode ultrasound often face challenges in distinguishing parathyroid adenoma (PA) from hyperplasia (PH). This study aimed to assess the qualitative and quantitative characteristics of parathyroid gland lesions using multiparametric ultrasound (MPUS).
Methods
Consecutive 85 patients with 98 parathyroid lesions and biochemically confirmed hyperparathyroidism (HPT) were enrolled in our prospective study prior to parathyroidectomy. MPUS included B-mode ultrasound, colour-doppler (CD), elastography and contrast-enhanced ultrasound (CEUS) with the subsequent qualitative and quantitative evaluation of obtained data. The findings from MPUS were compared to histopathological results obtained post-surgery.
Results
Eighty parathyroid adenomas were well-circumscribed and hypoechoic with increased central echogenicity (47.1%), peripheral-central vascularization (53%), polar feeding vessel (98%). Fourteen PH observed to have similar ultrasound appearance but were smaller in volume (p=0.038). Hyperplasias had a tendency for marked enhancement in CEUS after quantitative analysis vs. peripherally enhanced adenomas with central wash-out. We achieved 91.2% sensitivity and 73.5% specificity, 94% positive predictive value (PPV), 87.5% negative predictive value (NPV) and 87.5% accuracy in the differentiation of parathyroid lesions prior to post-processing. Our sensitivity increased up to 98%, specificity 80%, PPV 98%, NPV 80% with an accuracy of 96.5% after quantitative analysis.
Conclusions
CEUS of parathyroid lesions showed potential in the differentiation of adenoma from hyperplasia. The quantitative analysis enhanced the sensitivity and specificity of differentiation between parathyroid lesions.
| Original language | English |
|---|---|
| Pages | 49 |
| Number of pages | 1 |
| Publication status | Published - 18 Oct 2024 |
| Externally published | Yes |
| Event | 9th Baltic Congress of Radiology - Riga , Latvia Duration: 17 Oct 2024 → 19 Oct 2024 https://bcr2024.lv/bcr-2024-posters/ |
Congress
| Congress | 9th Baltic Congress of Radiology |
|---|---|
| Abbreviated title | BCR2024 |
| Country/Territory | Latvia |
| City | Riga |
| Period | 17/10/24 → 19/10/24 |
| Internet address |
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)