Abstract
Cases of long-term outcomes of a novel disease MIS-C have rarely been reported. The most common cardiac manifestations
of MIS-C are myocarditis, coronary artery aneurysms, conduction abnormalities, and arrhythmias. We report a case of an 8-year-old
boy, who has Asperger syndrome, with a complicated course of disease called MIS-C during Covid-19 outbreak, when this was the
first diagnosis of MIS-C in Latvia. The patient was tested positive for the SARS-CoV-2 (RNA) and Hemophilus influenza (DNA).
In 9th day of hospitalization, the diagnosis of MIS-C was performed. He had involvement of gastrointestinal, cardiovascular,
respiratory and coagulation systems. The patient received therapy with IVIG, Anakinra as well antibiotics and cardiovascular
medicine. During hospitalisation patient had complications such as anemia of a combined nature, post-infectious bone marrow
suppression, hepatosplenomegaly and candidiasis due to CVC. The cardiac magnetic resonance imaging (cMRI) after being
diagnosed with MIS-C revealed edema and focal changes in LV inferior wall, although volume of both ventricles and LV systolic
function were normal. A year after the follow-up cMRI, showed resolution of the myocardial edema. In existing literature there
are several cohort studies about long-term outcome of MIS-C myocarditis in 6 month follow-up visit, showing no evidence of scar
tissues in cMRI, but in some patients- diastolic dysfunction was detected. This report emphasizes a complicated form of disease in
patient who has Asperger syndrome with excellent outcome.
of MIS-C are myocarditis, coronary artery aneurysms, conduction abnormalities, and arrhythmias. We report a case of an 8-year-old
boy, who has Asperger syndrome, with a complicated course of disease called MIS-C during Covid-19 outbreak, when this was the
first diagnosis of MIS-C in Latvia. The patient was tested positive for the SARS-CoV-2 (RNA) and Hemophilus influenza (DNA).
In 9th day of hospitalization, the diagnosis of MIS-C was performed. He had involvement of gastrointestinal, cardiovascular,
respiratory and coagulation systems. The patient received therapy with IVIG, Anakinra as well antibiotics and cardiovascular
medicine. During hospitalisation patient had complications such as anemia of a combined nature, post-infectious bone marrow
suppression, hepatosplenomegaly and candidiasis due to CVC. The cardiac magnetic resonance imaging (cMRI) after being
diagnosed with MIS-C revealed edema and focal changes in LV inferior wall, although volume of both ventricles and LV systolic
function were normal. A year after the follow-up cMRI, showed resolution of the myocardial edema. In existing literature there
are several cohort studies about long-term outcome of MIS-C myocarditis in 6 month follow-up visit, showing no evidence of scar
tissues in cMRI, but in some patients- diastolic dysfunction was detected. This report emphasizes a complicated form of disease in
patient who has Asperger syndrome with excellent outcome.
Original language | English |
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Article number | 235 |
Journal | Archives of Pediatrics |
Volume | 8 |
Issue number | 1 |
DOIs | |
Publication status | Published - 20 Jan 2023 |
Keywords*
- COVID-19 Associated Multisystem Inflammatory Syndrome
- Cardiovascular complication
- Myocarditis
- Longterm outcome cMRI.
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)