Nanotechnology in vascular tissue engineering: from nanoscaffolding towards rapid vessel biofabrication

Vladimir Mironov, Vladimir Kasyanov, Roger R. Markwald

Research output: Contribution to journalReview articlepeer-review

105 Citations (Scopus)

Abstract

The existing methods of biofabrication for vascular tissue engineering are still bioreactor-based, extremely expensive, laborious and time consuming and, furthermore, not automated, which would be essential for an economically successful large-scale commercialization. The advances in nanotechnology can bring additional functionality to vascular scaffolds, optimize internal vascular graft surface and even help to direct the differentiation of stem cells into the vascular cell phenotype. The development of rapid nanotechnology-based methods of vascular tissue biofabrication represents one of most important recent technological breakthroughs in vascular tissue engineering because it dramatically accelerates vascular tissue assembly and, importantly, also eliminates the need for a bioreactor-based scaffold cellularization process.

Original languageEnglish
Pages (from-to)338-344
Number of pages7
JournalTrends in Biotechnology
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 2008
Externally publishedYes

Field of Science

  • 2.6 Medical engineering
  • 2.5 Materials engineering
  • 3.4 Medical biotechnology

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