TY - JOUR
T1 - Nanotechnology in vascular tissue engineering
T2 - from nanoscaffolding towards rapid vessel biofabrication
AU - Mironov, Vladimir
AU - Kasyanov, Vladimir
AU - Markwald, Roger R.
N1 - Funding Information:
This work was funded by grants from the National Science Foundation (Frontiers in Integrative Biological Research grant EF-0526854) and the Medical University of South Carolina Bioprinting Research Center.
PY - 2008/6
Y1 - 2008/6
N2 - The existing methods of biofabrication for vascular tissue engineering are still bioreactor-based, extremely expensive, laborious and time consuming and, furthermore, not automated, which would be essential for an economically successful large-scale commercialization. The advances in nanotechnology can bring additional functionality to vascular scaffolds, optimize internal vascular graft surface and even help to direct the differentiation of stem cells into the vascular cell phenotype. The development of rapid nanotechnology-based methods of vascular tissue biofabrication represents one of most important recent technological breakthroughs in vascular tissue engineering because it dramatically accelerates vascular tissue assembly and, importantly, also eliminates the need for a bioreactor-based scaffold cellularization process.
AB - The existing methods of biofabrication for vascular tissue engineering are still bioreactor-based, extremely expensive, laborious and time consuming and, furthermore, not automated, which would be essential for an economically successful large-scale commercialization. The advances in nanotechnology can bring additional functionality to vascular scaffolds, optimize internal vascular graft surface and even help to direct the differentiation of stem cells into the vascular cell phenotype. The development of rapid nanotechnology-based methods of vascular tissue biofabrication represents one of most important recent technological breakthroughs in vascular tissue engineering because it dramatically accelerates vascular tissue assembly and, importantly, also eliminates the need for a bioreactor-based scaffold cellularization process.
UR - http://www.scopus.com/inward/record.url?scp=43649085052&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2008.03.001
DO - 10.1016/j.tibtech.2008.03.001
M3 - Review article
C2 - 18423666
AN - SCOPUS:43649085052
SN - 0167-7799
VL - 26
SP - 338
EP - 344
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 6
ER -