Neurological manifestation of medium and large vessel vasculitis

Background and aims: Neurological manifestations of vasculitis are very diverse and have variable course. Nervous system vasculitis still is diagnostics and management challenge. Nervous system involvement is a common neurological complication, that is why neurologist have an important task to identify patients with systemic vasculitis and diagnose diseases.Methods: This is a retrospective clinical study of patients with neurological complications of large and medium vessel vasculitis, that ware treated and observed in Paul Stradins Clinical University Hospital from 2015 till 2019. Anamnesis and information about the disease evolvement, patients neurological status, patients common condition, treatment, medication and investigations was collected from available previous documentation. Within the framework of this study there was analized patients group and most common medium and large vessel vasculitis neurological complications.Results: In Paul Stradins Clinical University Hospital from 2015 till 2019 were treated 98 patients with medium and large vessel vasculitis diagnosis. 45 patients with Polyarteritis Nodosa diagnosis, 34 patients had Takayasu arteritis diagnosis and 19 patients had Giant cell arteritis diagnosis. Most often neurological complication was dizziness, which was observed in 48.2% of all patients, the other most spread and serious manifestation was cerebral stroke – 34.3% of all patients and 11.5% had visual disturbance.Conclusion: Vasculitis neurological manifestations are very diverse. Systemic vasculitis can affect any peripheral or central nervous system structure, causing variable neurological complications. Early neurological symptom identification allows to start treatment on time and improve outcomes. Without correct treatment neurological manifest-ations might be fatal, rapid diagnostic ant therapy prevents patients from serious disability. Disclosure: Nothing to disclose.