TY - JOUR
T1 - No relationship between generalised anxiety symptoms and cardiovascular autonomic dysfunction
AU - Kupats, Einars
AU - Noviks, Ilja
AU - Vrublevska, Jelena
AU - Kenina, Viktorija
AU - Kojalo, Una
AU - Logina, Inara
N1 - Funding Information:
This study was approved by the Ethics Committee of the Riga Stradins University, Riga, Latvia (No. 11/28.04.2016). The study was conducted in accordance with the Declaration of Helsinki and its subsequent amendments. All patients were enrolled after providing written informed consent.
Publisher Copyright:
© 2018 Elsevier GmbH
PY - 2018/12
Y1 - 2018/12
N2 - Purpose: Patients with generalised anxiety symptoms generally complain of autonomic arousal symptoms. The present study examined the relationships between cardiovascular autonomic dysfunction and generalised anxiety symptoms. Methods: Fifty-five participants including patients with generalised anxiety symptoms (n = 32) and healthy volunteers who served as controls (n = 23) were selected for this study. All participants completed the 7-item Generalised Anxiety Disorder Scale (GAD-7) questionnaire and underwent autonomic function tests, including the Ewing test battery and heart rate variability (HRV) test. Results: Autonomic function parameters included low frequency (LF, 0.04–0.15 Hz) power of HRV, high frequency (HF, 0.15–0.4 Hz) power, power spectrum density (PSD), LF/HF ratio, 30:15 ratio, heart rate response to deep breathing, Valsalva ratio, root-mean square differences of successive R-R intervals (RMSSD), standard deviation of the NN interval (SDNN), stress index (SI) and the Alpha 1 index. There were no significant differences in these parameters between the participants with generalised anxiety symptoms and control participants. Conclusions: The result of this study suggests that there is no statistically significant relationship between generalised anxiety symptoms and cardiovascular autonomic dysfunction.
AB - Purpose: Patients with generalised anxiety symptoms generally complain of autonomic arousal symptoms. The present study examined the relationships between cardiovascular autonomic dysfunction and generalised anxiety symptoms. Methods: Fifty-five participants including patients with generalised anxiety symptoms (n = 32) and healthy volunteers who served as controls (n = 23) were selected for this study. All participants completed the 7-item Generalised Anxiety Disorder Scale (GAD-7) questionnaire and underwent autonomic function tests, including the Ewing test battery and heart rate variability (HRV) test. Results: Autonomic function parameters included low frequency (LF, 0.04–0.15 Hz) power of HRV, high frequency (HF, 0.15–0.4 Hz) power, power spectrum density (PSD), LF/HF ratio, 30:15 ratio, heart rate response to deep breathing, Valsalva ratio, root-mean square differences of successive R-R intervals (RMSSD), standard deviation of the NN interval (SDNN), stress index (SI) and the Alpha 1 index. There were no significant differences in these parameters between the participants with generalised anxiety symptoms and control participants. Conclusions: The result of this study suggests that there is no statistically significant relationship between generalised anxiety symptoms and cardiovascular autonomic dysfunction.
KW - Cardiovascular autonomic dysfunction
KW - Ewing test battery
KW - Generalised anxiety
KW - Heart rate variability
UR - http://www.scopus.com/inward/record.url?scp=85049581011&partnerID=8YFLogxK
U2 - 10.1016/j.npbr.2018.07.001
DO - 10.1016/j.npbr.2018.07.001
M3 - Article
AN - SCOPUS:85049581011
SN - 0941-9500
VL - 30
SP - 86
EP - 90
JO - Neurology Psychiatry and Brain Research
JF - Neurology Psychiatry and Brain Research
ER -