Novel laboratory tests in assessment of liver function in cute and chronic liver diseases

Ludmila Viksna, Jāzeps Keišs, Arturs Sočņevs, Baiba Rozentale, Mara Pilmane, Natalija Sevastjanova, Inita Buiķe, Agita Jeruma, Elena Eglite, Kristīne Ābeltiņa, Valentīna Sondore

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
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Liver biopsy in clinical practice has been widely used for the diagnosis and management of patients with liver diseases, particularly, with chronic liver diseases. However, liver biopsy is an invasive method with potential complications, sampling and interpretation errors. Therefore, noninvasive tests are being developed and introduced to replace liver biopsy. The aim of the present study was to identify the new noninvasive methods to be used for the assessment of liver structure and function, by use of the appropriate serum surrogate markers and to evaluate the clinical diagnostic and prognostic accuracy of these methods, including immunogenetic methods, in cases of acute and chronic liver diseases. The obtained data showed that serum markers of apoptosis (cytokeratin-18 neoepitope and citochrome c) and fibrosis (hyaluronic acid) should be included in viral and toxic liver damage management algorithms. The punctual identification of immunogenetic factors (HLA class II antigens) may prove to be useful in predicting disease evolution, and in guiding the appropriate therapy for patients with poor prognosis.

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Issue number4-5
Publication statusPublished - 2009


  • Apoptosis fibrosis
  • HLA class II antigens
  • Liver diseases

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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