TY - JOUR
T1 - Obstetric Outcomes in Women with Rheumatic Disease and COVID-19 in the Context of Vaccination Status
AU - Maguire, Sinead
AU - COVID-19 Global Rheumatology Alliance
A2 - Al-Emadi, Samar
A2 - Alba, Paula
A2 - Aguiar, Mathia Cecilia
A2 - Lawati, Talal Al
A2 - Alle, Gelsomina
A2 - Bermas, Bonnie
A2 - Bhana, Suleman
A2 - Branimir, Anic
A2 - Bulina, Inita
A2 - Clowse, Megan
A2 - Cogo, Karina
A2 - Colunga, Iris
A2 - Cook, Claire
A2 - Cortez, Karen J
A2 - Dao, Kathryn
A2 - Gianfrancesco, Milena
A2 - Gore-Massey, Monique
A2 - Gossec, Laure
A2 - Grainger, Rebecca
A2 - Hausman, Jonathon
A2 - Hsu, Tiffany Y T
A2 - Hyrich, Kimme
A2 - Isnardi, Carolina
A2 - Kawano, Yumeko
A2 - Kilding, Rachael
A2 - Kusevich, Daria A
A2 - Lawson-Tovey, Saskia
A2 - Liew, Jean
A2 - McCarthy, Eoghan
A2 - Montgumery, Anna
A2 - Moyano, Sebastian
A2 - Nasir, Noreen
A2 - Padjen, Ivan
A2 - Papagoras, Charalampos
A2 - Patel, Naomi J
A2 - Pera, Mariana
A2 - Pisoni, Cecilia
A2 - Pons-Estel, Guillermo
A2 - Quiambao, Antonio L
A2 - Quintana, Rosana
A2 - Ruderman, Eric
A2 - Sattui, Sebastian
A2 - Savio, Veronica
A2 - Sciascia, Savino
A2 - Sencarova, Marieta
A2 - Morales, Rosa Serrano
A2 - Siddique, Faizah
A2 - Sirotich, Emily
A2 - Zepa, Julija
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.
PY - 2022/9/19
Y1 - 2022/9/19
N2 - OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy.METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi -square or Fisher's exact test.RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2%(n = 2).CONCLUSION: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.
AB - OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy.METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi -square or Fisher's exact test.RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2%(n = 2).CONCLUSION: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.
KW - Rheumatic COVID-19 obstetric
UR - https://pubmed.ncbi.nlm.nih.gov/36124987/
UR - https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/MEDLINE:36124987
U2 - 10.1093/rheumatology/keac534
DO - 10.1093/rheumatology/keac534
M3 - Article
C2 - 36124987
SN - 1462-0324
JO - Rheumatology
JF - Rheumatology
ER -