Obstetric Outcomes in Women with Rheumatic Disease and COVID-19 in the Context of Vaccination Status

Sinead Maguire; COVID-19 Global Rheumatology Alliance; Inita Bulina; Julija Zepa

doi:10.1093/rheumatology/keac534

Obstetric Outcomes in Women with Rheumatic Disease and COVID-19 in the Context of Vaccination Status

Sinead Maguire (Coresponding Author), COVID-19 Global Rheumatology Alliance, Inita Bulina (Member of the Working Group), Julija Zepa (Member of the Working Group)

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy.

METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi -square or Fisher's exact test.

RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2%(n = 2).

CONCLUSION: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

Original language	English
Number of pages	6
Journal	Rheumatology
DOIs	https://doi.org/10.1093/rheumatology/keac534
Publication status	E-pub ahead of print - 19 Sept 2022

Keywords*

Rheumatic COVID-19 obstetric

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/rheumatology/keac534

Cite this

@article{80eb7a0e805941f8bf77ae4fd2107d22,

title = "Obstetric Outcomes in Women with Rheumatic Disease and COVID-19 in the Context of Vaccination Status",

abstract = "OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy.METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi -square or Fisher's exact test.RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2%(n = 2).CONCLUSION: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.",

keywords = "Rheumatic COVID-19 obstetric",

author = "Sinead Maguire and {COVID-19 Global Rheumatology Alliance} and Samar Al-Emadi and Paula Alba and Aguiar, {Mathia Cecilia} and Lawati, {Talal Al} and Gelsomina Alle and Bonnie Bermas and Suleman Bhana and Anic Branimir and Inita Bulina and Megan Clowse and Karina Cogo and Iris Colunga and Claire Cook and Cortez, {Karen J} and Kathryn Dao and Milena Gianfrancesco and Monique Gore-Massey and Laure Gossec and Rebecca Grainger and Jonathon Hausman and Hsu, {Tiffany Y T} and Kimme Hyrich and Carolina Isnardi and Yumeko Kawano and Rachael Kilding and Kusevich, {Daria A} and Saskia Lawson-Tovey and Jean Liew and Eoghan McCarthy and Anna Montgumery and Sebastian Moyano and Noreen Nasir and Ivan Padjen and Charalampos Papagoras and Patel, {Naomi J} and Mariana Pera and Cecilia Pisoni and Guillermo Pons-Estel and Quiambao, {Antonio L} and Rosana Quintana and Eric Ruderman and Sebastian Sattui and Veronica Savio and Savino Sciascia and Marieta Sencarova and Morales, {Rosa Serrano} and Faizah Siddique and Emily Sirotich and Julija Zepa",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology.",

year = "2022",

month = sep,

day = "19",

doi = "10.1093/rheumatology/keac534",

language = "English",

journal = "Rheumatology",

issn = "1462-0324",

publisher = "Oxford University Press",

}

TY - JOUR

T1 - Obstetric Outcomes in Women with Rheumatic Disease and COVID-19 in the Context of Vaccination Status

AU - Maguire, Sinead

AU - COVID-19 Global Rheumatology Alliance

A2 - Al-Emadi, Samar

A2 - Alba, Paula

A2 - Aguiar, Mathia Cecilia

A2 - Lawati, Talal Al

A2 - Alle, Gelsomina

A2 - Bermas, Bonnie

A2 - Bhana, Suleman

A2 - Branimir, Anic

A2 - Bulina, Inita

A2 - Clowse, Megan

A2 - Cogo, Karina

A2 - Colunga, Iris

A2 - Cook, Claire

A2 - Cortez, Karen J

A2 - Dao, Kathryn

A2 - Gianfrancesco, Milena

A2 - Gore-Massey, Monique

A2 - Gossec, Laure

A2 - Grainger, Rebecca

A2 - Hausman, Jonathon

A2 - Hsu, Tiffany Y T

A2 - Hyrich, Kimme

A2 - Isnardi, Carolina

A2 - Kawano, Yumeko

A2 - Kilding, Rachael

A2 - Kusevich, Daria A

A2 - Lawson-Tovey, Saskia

A2 - Liew, Jean

A2 - McCarthy, Eoghan

A2 - Montgumery, Anna

A2 - Moyano, Sebastian

A2 - Nasir, Noreen

A2 - Padjen, Ivan

A2 - Papagoras, Charalampos

A2 - Patel, Naomi J

A2 - Pera, Mariana

A2 - Pisoni, Cecilia

A2 - Pons-Estel, Guillermo

A2 - Quiambao, Antonio L

A2 - Quintana, Rosana

A2 - Ruderman, Eric

A2 - Sattui, Sebastian

A2 - Savio, Veronica

A2 - Sciascia, Savino

A2 - Sencarova, Marieta

A2 - Morales, Rosa Serrano

A2 - Siddique, Faizah

A2 - Sirotich, Emily

A2 - Zepa, Julija

PY - 2022/9/19

Y1 - 2022/9/19

N2 - OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy.METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi -square or Fisher's exact test.RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2%(n = 2).CONCLUSION: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

AB - OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy.METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi -square or Fisher's exact test.RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2%(n = 2).CONCLUSION: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

KW - Rheumatic COVID-19 obstetric

UR - https://pubmed.ncbi.nlm.nih.gov/36124987/

UR - https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/MEDLINE:36124987

U2 - 10.1093/rheumatology/keac534

DO - 10.1093/rheumatology/keac534

M3 - Article

C2 - 36124987

SN - 1462-0324

JO - Rheumatology

JF - Rheumatology

ER -

Obstetric Outcomes in Women with Rheumatic Disease and COVID-19 in the Context of Vaccination Status

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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