On the influence of apomorphine on the toxicity of adrenalin and phenamine

M. L. Belenkii, M. A. Vitolinya, R. O. Vitoliņa

Research output: Contribution to journalArticlepeer-review

Abstract

Experiments on albino mice were used to determine the average lethal, doses of apomorphine, adrenalin, phenamine, and mixtures of apomorphine with adrenalin (1:3 and 3:1) and apomorphine with phenamine (1:3 and 3:1). The obtained values of average lethal doses for the mixtures were compared with those calculated according to these formulas: (1/LD50M)=(Pa/LD50a)+(Pb/LD50b), where LD50M is the average lethal dose of the mixture. LD50a and LD50b are the average lethal doses of its components and pa and pb are portions of the components in a mixture (pa+pb=1). This formula determines the relationship between the average lethal doses of a mixture and its components in case the latter's action is additive. It was shown that the effect of the combined action of apomorphine with adrenalin was considerably in excess of the additive effect whereas the effect of the combined action of apomorphine with phenamine was significantly less than the additive effect. These results were discussed from the viewpoint of the importance of pyrocatechol-O-methyltransferase in the inactivation of pyrocatecholamines.

Original languageEnglish
Pages (from-to)542-544
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume61
Issue number5
DOIs
Publication statusPublished - May 1966
Externally publishedYes

Field of Science

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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