Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats

Baiba Jansone; Lena Bergstrom; Simons Svirskis; Jonas Lindblom; Vija Klusa; Jarl E.S. Wikberg

doi:10.1016/j.neulet.2003.12.006

Opposite effects of γ₁- and γ₂-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats

Baiba Jansone, Lena Bergstrom, Simons Svirskis, Jonas Lindblom, Vija Klusa, Jarl E.S. Wikberg

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

By use of the brain microdialysis technique we show that administration of γ₁-melanocyte stimulating hormone (γ₁-MSH) into the ventral tegmental area of anaesthetized rats causes an increase in the release of extracellular dopamine and its metabolite 3,4-dihydroxyphenylacetic acid in the nucleus accumbens, while γ₂-MSH causes the opposite effect. Moreover, γ₂-MSH pre-treatment considerably reduced the γ₁-MSH-induced effects. Our findings suggest an opposing action of two γ-MSH-activated pathways on the mesolimbic dopaminergic system, which could be important in the maintenance of a balanced psychoactivation state.

Original language	English
Pages (from-to)	68-71
Number of pages	4
Journal	Neuroscience Letters
Volume	361
Issue number	1-3
DOIs	https://doi.org/10.1016/j.neulet.2003.12.006
Publication status	Published - 6 May 2004
Externally published	Yes

Keywords*

3,4-Dihydroxyphenylacetic acid
Dopamine
Melanocyte stimulating hormone γ
Microdialysis
Nucleus accumbens
Ventral tegmental area

Field of Science*

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.neulet.2003.12.006

Cite this

@article{af8e03f7ece241edab828aad26e541a4,

title = "Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats",

abstract = "By use of the brain microdialysis technique we show that administration of γ1-melanocyte stimulating hormone (γ1-MSH) into the ventral tegmental area of anaesthetized rats causes an increase in the release of extracellular dopamine and its metabolite 3,4-dihydroxyphenylacetic acid in the nucleus accumbens, while γ2-MSH causes the opposite effect. Moreover, γ2-MSH pre-treatment considerably reduced the γ1-MSH-induced effects. Our findings suggest an opposing action of two γ-MSH-activated pathways on the mesolimbic dopaminergic system, which could be important in the maintenance of a balanced psychoactivation state.",

keywords = "3,4-Dihydroxyphenylacetic acid, Dopamine, Melanocyte stimulating hormone γ, Microdialysis, Nucleus accumbens, Ventral tegmental area",

author = "Baiba Jansone and Lena Bergstrom and Simons Svirskis and Jonas Lindblom and Vija Klusa and Wikberg, \{Jarl E.S.\}",

note = "Funding Information: Supported by the Latvian Council of Science PhD fellowship grant No. 586, Swedish MRC (04X-05957) and Melacure Therapeutics AB.",

year = "2004",

month = may,

day = "6",

doi = "10.1016/j.neulet.2003.12.006",

language = "English",

volume = "361",

pages = "68--71",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1-3",

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TY - JOUR

T1 - Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats

AU - Jansone, Baiba

AU - Bergstrom, Lena

AU - Svirskis, Simons

AU - Lindblom, Jonas

AU - Klusa, Vija

AU - Wikberg, Jarl E.S.

N1 - Funding Information: Supported by the Latvian Council of Science PhD fellowship grant No. 586, Swedish MRC (04X-05957) and Melacure Therapeutics AB.

PY - 2004/5/6

Y1 - 2004/5/6

N2 - By use of the brain microdialysis technique we show that administration of γ1-melanocyte stimulating hormone (γ1-MSH) into the ventral tegmental area of anaesthetized rats causes an increase in the release of extracellular dopamine and its metabolite 3,4-dihydroxyphenylacetic acid in the nucleus accumbens, while γ2-MSH causes the opposite effect. Moreover, γ2-MSH pre-treatment considerably reduced the γ1-MSH-induced effects. Our findings suggest an opposing action of two γ-MSH-activated pathways on the mesolimbic dopaminergic system, which could be important in the maintenance of a balanced psychoactivation state.

AB - By use of the brain microdialysis technique we show that administration of γ1-melanocyte stimulating hormone (γ1-MSH) into the ventral tegmental area of anaesthetized rats causes an increase in the release of extracellular dopamine and its metabolite 3,4-dihydroxyphenylacetic acid in the nucleus accumbens, while γ2-MSH causes the opposite effect. Moreover, γ2-MSH pre-treatment considerably reduced the γ1-MSH-induced effects. Our findings suggest an opposing action of two γ-MSH-activated pathways on the mesolimbic dopaminergic system, which could be important in the maintenance of a balanced psychoactivation state.

KW - 3,4-Dihydroxyphenylacetic acid

KW - Dopamine

KW - Melanocyte stimulating hormone γ

KW - Microdialysis

KW - Nucleus accumbens

KW - Ventral tegmental area

UR - https://www.scopus.com/pages/publications/2342483728

U2 - 10.1016/j.neulet.2003.12.006

DO - 10.1016/j.neulet.2003.12.006

M3 - Article

C2 - 15135895

AN - SCOPUS:2342483728

SN - 0304-3940

VL - 361

SP - 68

EP - 71

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-3

ER -