Optimised Routines for Monitoring of Treated Late Latent Syphilis Patients

Dzintars Ozoliņš, Ilona Hartmane, Ingmārs Mikažāns, Daina Paegle, Ināra Ančupāne, Aija Žileviča

Research output: Contribution to journalArticlepeer-review


Highly sensitive and specific tests are needed in monitoring of the serological activity and efficacy of treatment of late latent syphilis. In a retrospective study, the data of 52 patients who had received treatment for late latent syphilis were analysed in the Clinical Centre of Skin and Sexually Transmitted Diseases, Latvia. The diagnostic sensitivity and specificity was calculated by Syphilis Immunoblot IgG, Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Express Diagnosis (SED). The correlation between Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Immunoblot IgG, SED and TPIR results were estimated. Syphilis Immunoblot IgG is useful for latent syphilis diagnostics. The values of the synthetic peptide TmpA, TmpN15 and TmpN47 on the Syphilis Immunoblot IgG strip are useful for monitoring of the treatment of late latent syphilis patients.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Issue number6
Publication statusPublished - Jan 2008
Externally publishedYes


  • serological diagnostics
  • syphilis
  • treatment monitoring

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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