Optimised Routines for Monitoring of Treated Late Latent Syphilis Patients

Highly sensitive and specific tests are needed in monitoring of the serological activity and efficacy of treatment of late latent syphilis. In a retrospective study, the data of 52 patients who had received treatment for late latent syphilis were analysed in the Clinical Centre of Skin and Sexually Transmitted Diseases, Latvia. The diagnostic sensitivity and specificity was calculated by Syphilis Immunoblot IgG, Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Express Diagnosis (SED). The correlation between Treponema Pallidum Immobilisation Reaction (TPIR) and Syphilis Immunoblot IgG, SED and TPIR results were estimated. Syphilis Immunoblot IgG is useful for latent syphilis diagnostics. The values of the synthetic peptide TmpA, TmpN15 and TmpN47 on the Syphilis Immunoblot IgG strip are useful for monitoring of the treatment of late latent syphilis patients.