Oregonin reduces lipid accumulation and proinflammatory responses in primary human macrophages

Annika Lundqvist, Lisa U. Magnusson, Christina Ullström, Jelena Krasilnikova, Galina Telysheva, Tatjana Dizhbite, Lillemor Mattsson Hultén

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Inflammation in the vascular wall is important for the development of atherosclerosis. We have previously shown that inflammatory macrophages are more abundant in human atherosclerotic lesions than in healthy arteries. Activated macrophages produce reactive oxygen species (ROS) that promote local inflammation in atherosclerotic lesions. Here, we investigated the role of oregonin, a diarylheptanoid, on proinflammatory responses in primary human macrophages and found that oregonin decreased cellular lipid accumulation and proinflammatory cytokine secretion. We also found that oregonin decreased ROS production in macrophages. Additionally, we observed that treatment of lipopolysaccharide-exposed macrophages with oregonin significantly induced the expression of antioxidant-related genes, including Heme oxygenase-1 and NADPH dehydrogenase quinone 1. In summary, we have shown that oregonin reduces lipid accumulation, inflammation and ROS production in primary human macrophages, indicating that oregonin has anti-inflammatory bioactivities.

Original languageEnglish
Pages (from-to)693-699
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume458
Issue number3
DOIs
Publication statusPublished - 13 Mar 2015

Keywords

  • Anti-inflammatory
  • Cytokines
  • Lipid accumulation
  • Macrophages
  • Oregonin

Field of Science

  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'Oregonin reduces lipid accumulation and proinflammatory responses in primary human macrophages'. Together they form a unique fingerprint.

Cite this