TY - JOUR
T1 - Oregonin reduces lipid accumulation and proinflammatory responses in primary human macrophages
AU - Lundqvist, Annika
AU - Magnusson, Lisa U.
AU - Ullström, Christina
AU - Krasilnikova, Jelena
AU - Telysheva, Galina
AU - Dizhbite, Tatjana
AU - Hultén, Lillemor Mattsson
N1 - Funding Information:
This work was supported by the Swedish Research Council ( 521-2013-3588 ), the Swedish Heart-Lung Foundation ( 20130231 ), and Laboratory Medicine, Sahlgrenska University Hospital , Gothenburg Sweden.
Publisher Copyright:
© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
PY - 2015/3/13
Y1 - 2015/3/13
N2 - Inflammation in the vascular wall is important for the development of atherosclerosis. We have previously shown that inflammatory macrophages are more abundant in human atherosclerotic lesions than in healthy arteries. Activated macrophages produce reactive oxygen species (ROS) that promote local inflammation in atherosclerotic lesions. Here, we investigated the role of oregonin, a diarylheptanoid, on proinflammatory responses in primary human macrophages and found that oregonin decreased cellular lipid accumulation and proinflammatory cytokine secretion. We also found that oregonin decreased ROS production in macrophages. Additionally, we observed that treatment of lipopolysaccharide-exposed macrophages with oregonin significantly induced the expression of antioxidant-related genes, including Heme oxygenase-1 and NADPH dehydrogenase quinone 1. In summary, we have shown that oregonin reduces lipid accumulation, inflammation and ROS production in primary human macrophages, indicating that oregonin has anti-inflammatory bioactivities.
AB - Inflammation in the vascular wall is important for the development of atherosclerosis. We have previously shown that inflammatory macrophages are more abundant in human atherosclerotic lesions than in healthy arteries. Activated macrophages produce reactive oxygen species (ROS) that promote local inflammation in atherosclerotic lesions. Here, we investigated the role of oregonin, a diarylheptanoid, on proinflammatory responses in primary human macrophages and found that oregonin decreased cellular lipid accumulation and proinflammatory cytokine secretion. We also found that oregonin decreased ROS production in macrophages. Additionally, we observed that treatment of lipopolysaccharide-exposed macrophages with oregonin significantly induced the expression of antioxidant-related genes, including Heme oxygenase-1 and NADPH dehydrogenase quinone 1. In summary, we have shown that oregonin reduces lipid accumulation, inflammation and ROS production in primary human macrophages, indicating that oregonin has anti-inflammatory bioactivities.
KW - Anti-inflammatory
KW - Cytokines
KW - Lipid accumulation
KW - Macrophages
KW - Oregonin
UR - http://www.scopus.com/inward/record.url?scp=84924080685&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2015.01.161
DO - 10.1016/j.bbrc.2015.01.161
M3 - Article
C2 - 25686497
AN - SCOPUS:84924080685
SN - 0006-291X
VL - 458
SP - 693
EP - 699
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -
