Organ printing: Computer-aided jet printer-based three-dimensional tissue engineering

Vladimir Mironov, Thomas Boland, Chris Wilson, Elisabeth Roth, Anna Gutowska, Vladimir Kasyanov, Carol Eisenberg, Adrian Neagu, Gabor Forgacs, Roger R. Markwald

Research output: Contribution to conferencePaperpeer-review

1 Citation (Scopus)

Abstract

The development of rapid prototyping technologies including the "printing" of biodegradable scaffolds is a fasten growing field of tissue engineering. Here, we report about the development a novel computer-aided jet-based printer for organ printing. This cost effective, high throughput printer was shown to be very useful for two-dimensional molecular and cellular printing. We also show that it is possible to obtain 3-dimensional tissue constructs using a computer-driven, jet-based cell printer, a nontoxic thermo-reversible gel, cell aggregates of stem cells taken from bone marrow and perfusion bioreactor. It was demonstrated in vitro that closely placed explants of embryonic mesenchymal cushion tissue in three-dimensional collagen type 1 gel can fuse into ring-like and tubular structures. Similarly, printed cell aggregates fused and evolved into 3-dimensional, ring-like structure. Finally, a novel mathematical model of the cell-aggregates fusion process in the three-dimensional gels was developed. Taken together these data demonstrate the feasibility of computer-aided, three-dimensional tissue and organ printing.

Original languageEnglish
Pages9
Number of pages1
Publication statusPublished - 2002
EventThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products - Atlanta, GA, United States
Duration: 13 Oct 200216 Oct 2002

Conference

ConferenceThird Smith and Nephew International Symposium - Translating Tissue Engineering into Products
Country/TerritoryUnited States
CityAtlanta, GA
Period13/10/0216/10/02

Field of Science

  • 2.6 Medical engineering
  • 3.4 Medical biotechnology

Publication Type

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

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