Organ printing: Promises and challenges

Vladimir Mironov, Vladimir Kasyanov, Christopher Drake, Roger R. Markwald

Research output: Contribution to journalArticlepeer-review

175 Citations (Scopus)

Abstract

Organ printing or biomedical application of rapid prototyping, also defined as additive layer-by-layer biomanufacturing, is an emerging transforming technology that has potential for surpassing traditional solid scaffold-based tissue engineering. Organ printing has certain advantages: it is an automated approach that offers a pathway for scalable reproducible mass production of tissue engineered products; it allows a precised simultaneous 3D positioning of several cell types; it enables creation tissue with a high level of cell density; it can solve the problem of vascularization in thick tissue constructs; finally, organ printing can be done in situ. The ultimate goal of organ-printing technology is to fabricate 3D vascularized functional living human organs suitable for clinical, implantation. The main practical outcomes of organ-printing technology are industrial scalable robotic biofabrication of complex human tissues and organs, automated tissue-based in vitro assays for clinical diagnostics, drug discovery and drug toxicity, and complex in vitro models of human diseases. This article describes conceptual framework and recent developments in organ-printing technology, outlines main technological barriers and challenges, and presents potential future practical applications.

Original languageEnglish
Pages (from-to)93-103
Number of pages11
JournalRegenerative Medicine
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

Keywords*

  • Bioprinter
  • Organ printing
  • Tissue engineering
  • Tissue fusion
  • Tissue spheroids

Field of Science*

  • 3.4 Medical biotechnology
  • 2.6 Medical engineering

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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