Abstract
Cleft lip and palate (CLP) is a common congenital anomaly with a complex etiology which has not been elucidated yet. This study investigated whether expression of osteopontin (OPN), osteoprotegerin (OPG), and osteocalcin (OC), which are essential for the normal craniofacial bone remodelling, is not regulated in children with CLP. Alveolar bone tissue samples were obtained from patients with complete bilateral (CB) CLP (n= 14) during corrective plastic surgery and unaffected control subjects (n= 9). OPN, OPG, and OC expression was assessed by immunohistochemistry, and data were analyzed with the Mann-Whitney test. OPN expression was observed only sporadically in the alveolar bone of 3 patients, in contrast to the control group (z= - 2.962; P< 0.003). The number of OPG-positive bone cells varied from occasional to moderate, in contrast to the control group (z= - 2.247; P= 0.025). OC-positive osteocytes were present in moderate to numerous numbers in both patients and controls, with no significant difference between them (z= - 1.356; P< 0.175). The prominent expression of OC characteristic for CBCLP affected hard tissue indicates a high potential of bone mineralization. Few OPG-positive osteocytes in the bone tissue implicate the disregulation of osteoclast differentiation, maturation, and activity, but few OPN-containing cells may prove the common disregulation of bone remodelling during cleft morphopathogenesis.
Original language | English |
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Title of host publication | 5th International Interdisciplinary Scientific Conference SOCIETY. HEALTH. WELFARE |
Editors | A. Vētra, L. Vilka |
Publisher | EDP Sciences |
Number of pages | 9 |
Volume | 30 |
ISBN (Print) | 978-2-7598-9007-1 |
DOIs | |
Publication status | Published - 2016 |
Event | 5th International Interdisciplinary Scientific Conference "Society. Health. Welfare" - Riga, Latvia Duration: 26 Nov 2014 → 28 Nov 2014 Conference number: 5 |
Publication series
Name | SHS Web of Conferences |
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ISSN (Print) | 2261-2424 |
Conference
Conference | 5th International Interdisciplinary Scientific Conference "Society. Health. Welfare" |
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Country/Territory | Latvia |
City | Riga |
Period | 26/11/14 → 28/11/14 |
Field of Science*
- 3.1 Basic medicine
Publication Type*
- 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database