Osteopontin, osteocalcin, and osteoprotegerin expression in human tissue affected by cleft lip and palate

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Abstract

Cleft lip and palate (CLP) is a common congenital anomaly with a complex etiology which has not been elucidated yet. This study investigated whether expression of osteopontin (OPN), osteoprotegerin (OPG), and osteocalcin (OC), which are essential for the normal craniofacial bone remodelling, is not regulated in children with CLP. Alveolar bone tissue samples were obtained from patients with complete bilateral (CB) CLP (n= 14) during corrective plastic surgery and unaffected control subjects (n= 9). OPN, OPG, and OC expression was assessed by immunohistochemistry, and data were analyzed with the Mann-Whitney test. OPN expression was observed only sporadically in the alveolar bone of 3 patients, in contrast to the control group (z= - 2.962; P< 0.003). The number of OPG-positive bone cells varied from occasional to moderate, in contrast to the control group (z= - 2.247; P= 0.025). OC-positive osteocytes were present in moderate to numerous numbers in both patients and controls, with no significant difference between them (z= - 1.356; P< 0.175). The prominent expression of OC characteristic for CBCLP affected hard tissue indicates a high potential of bone mineralization. Few OPG-positive osteocytes in the bone tissue implicate the disregulation of osteoclast differentiation, maturation, and activity, but few OPN-containing cells may prove the common disregulation of bone remodelling during cleft morphopathogenesis.
Original languageEnglish
Title of host publication5th International Interdisciplinary Scientific Conference SOCIETY. HEALTH. WELFARE
EditorsA. Vētra, L. Vilka
PublisherEDP Sciences
Number of pages9
Volume30
ISBN (Print)978-2-7598-9007-1
DOIs
Publication statusPublished - 2016
Event5th International Interdisciplinary Scientific Conference SOCIETY. HEALTH. WELFARE - Riga, Latvia
Duration: 26 Nov 201428 Nov 2014
Conference number: 5

Publication series

NameSHS Web of Conferences
ISSN (Print)2261-2424

Conference

Conference5th International Interdisciplinary Scientific Conference SOCIETY. HEALTH. WELFARE
Country/TerritoryLatvia
CityRiga
Period26/11/1428/11/14

Field of Science*

  • 3.1 Basic medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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